与IGFBP-3相关的RXRα、STAT-1信号通路在β-淀粉样肽1～42诱导大鼠海马神经元凋亡中的可能作用

陈丽敏; 陈晓春; 潘晓东

解剖学报 ›› 2008, Vol. 39 ›› Issue (6) : 810-815.

论著

与IGFBP-3相关的RXRα、STAT-1信号通路在β-淀粉样肽_{1～42诱导大鼠海马神经元凋亡中的可能作用}

陈丽敏 ;陈晓春* ;潘晓东

作者信息 +

EFFECTS OF IGFBP-3/RXRα OR STAT-1 SIGNALING PATHWAY ON AβSUB>1-42/SUB> INDUCED APOPTOSIS IN RAT HIPPOCAMPUS NEURONS

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Abstract

Objective To investigate the effects of IGFBP-3, RXRα and STAT-1 on AβSUB>1-42/SUB> induced apoptosis in rat hippocampus neurons. Methods Apoptosis was induced by fibrillar AβSUB>1-42/SUB>. The percentage of neurons apoptosis was evaluated by microscopy after staining with TUNEL/DAPI. IGFBP-3 and RXRα positive neurons were observed by immunofluorescence. The expression of RXRα and STAT-1 protein were detected by Western blotting. Results After treatment with 20μmol/L AβSUB>1-42/SUB> for 24 hours, the apoptotic hippocampus neurons were shown by TUNEL/DAPI assay. The percentage of apoptotic neurons was increased in a time-dependent manner. During the development of apoptosis, both the percentage of IGFBP-3/ RXRα positive neurons and the expression of RXRα protein increased markedly after 3-6hours (EM>P/EM><0.01). However, the expression of STAT-1 protein significantly dec

导出引用

陈丽敏;陈晓春;潘晓东. 与IGFBP-3相关的RXRα、STAT-1信号通路在β-淀粉样肽_{1～42诱导大鼠海马神经元凋亡中的可能作用}[J]. 解剖学报. 2008, 39(6): 810-815

EFFECTS OF IGFBP-3/RXRα OR STAT-1 SIGNALING PATHWAY ON AβSUB>1-42/SUB> INDUCED APOPTOSIS IN RAT HIPPOCAMPUS NEURONS[J]. Acta Anatomica Sinica. 2008, 39(6): 810-815

中图分类号： R592