Objective To study the localization and morphology of 5hydroxytryptamine(5-HT),somatostatin(SS),gastrin(Gas),glucagon(Glu),substance P(SP), pancreatic polypeptide(PP) endocrine cells in the digestive tract of Eremias argus. Methods The ABC (avidinbiotin compex method) immunohistochemical method was used. Results 5-HT cells distributed more widely than the other five kinds of endocrine cells in the digestive tract, and they were observed throughout the digestive tract, from the esophagus to the rectum. In addition, the density of 5HT cells was the highest in the jejunum. SS cells were not found in the esophagus or the rectum. The distributive density of SS cells was the highest in the stomach. Gas cells and PP cells distributed in the pyloricus and the small intestine with the highest density in the duodenum. Glu cells distributed mainly in the pyloricus，duodenum and jejunum, the distributive density in the pyloricus was higher than other part obviously. We did not find any SP cell in the digestive tract of Eremias argus. Conclusion The five kinds of endocrine cells which we studied in this paper were mainly round and shuttledshape, which widely lied between epithelial cells, between glandular epithelial cells and at the b