禁止交配下调成年雌性大鼠乳腺组织雌二醇水平及雌激素受体α的表达

谢怡; 许舸; 刘孝云; 蔡家春; 张晓丽; 杨戎; 魏莎莉

解剖学报 ›› 2008, Vol. 39 ›› Issue (5) : 738-741.

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禁止交配下调成年雌性大鼠乳腺组织雌二醇水平及雌激素受体α的表达

谢怡 ^{1*; 许舸^{2 ;刘孝云^{1; 蔡家春^{3; 张晓丽^{3 ;杨戎^{1 ;魏莎莉¹}}}}}}

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COPULATION ABSTINENCE DOWNREGULATED ESTRADIOL LEVEL AND ERα EXPRESSION IN MAMMARY GLAND TISSUE OF ADULT FEMALE RATS

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Abstract

Objective To investigate the effects of copulation abstinence on estradiol levels and estrogen receptor-α(ERα) expression in the mammary gland of adult female rats. Methods Twelve 8-week-old female SpragueDawley (SD) rats were randomly divided into two groups: control(copulation) and copulation abstinence. Histological changes of the mammary gland tissue samples was assessed by light and electron microscopic methods and ERα protein was detected by immunohistochemistry and Western blotting analysis. The estradiol levels in serum and mammary gland tissue were measured by radioimmunoassay. Results After a 60-day abstinence period, mammary estradiol levels were reduced (EM>P/EM><0.05). Moreover, ERα protein in the mammary gland tissue was downregulated (EM>P/EM><0.05). No morphological changes was observed in the mammary tissue sections. Conclusion Our results indicate sexual abstinence induced dec

导出引用

谢怡 ;许舸 ;刘孝云;蔡家春;张晓丽;杨戎;魏莎莉. 禁止交配下调成年雌性大鼠乳腺组织雌二醇水平及雌激素受体α的表达[J]. 解剖学报. 2008, 39(5): 738-741

COPULATION ABSTINENCE DOWNREGULATED ESTRADIOL LEVEL AND ERα EXPRESSION IN MAMMARY GLAND TISSUE OF ADULT FEMALE RATS[J]. Acta Anatomica Sinica. 2008, 39(5): 738-741

中图分类号： R339.23