槲皮素和乙酸龙脑酯对细菌脂多糖诱导流产孕小鼠子宫组织中CD4+/CD8+ T细胞的影响

王晓丹; 史万玉; 马爱团; 姜国均; 张建楼; 翟向和; 钟秀会

解剖学报 ›› 2008, Vol. 39 ›› Issue (5) : 734-737.

论著

槲皮素和乙酸龙脑酯对细菌脂多糖诱导流产孕小鼠子宫组织中CD4^{+/CD8^{+ T细胞的影响}}

王晓丹^{1,2; 史万玉^{1 ;马爱团^{2 ;姜国均^{2 ;张建楼^{2 ;翟向和^{2 ;钟秀会^1*}}}}}}

作者信息 +

INFLUENCE OF QUERCETIN AND BORNYL ACETATE ON CD4SUP>+ /SUP>/CD8SUP>+/SUP>T LYMPHOCYTES IN THE UTERUS FOLLOWING LPSINDUCED ABORTION IN PREGNANT MICE

Author information +

文章历史 +

Abstract

Objective To investigate the significance of CD4SUP>+ /SUP>and CD8SUP>+/SUP> T lymphocytes in the uterus in early embryo loss (or resorption), and to elucidate the anti-bortive effect and the immunological modulation of the maternalfetal interaction with quercetin and bornyl acetate. Methods Lipopolysaccharide (LPS)（0.10μg/mouse）was injected via the tail vein in order to induce abortion in 7-day-gestation mice which also received quercetin and bornyl acetate at days 4-7 of gestation. Uterine CD4SUP>+/SUP> and CD8SUP>+/SUP> T lymphocytes of each group (EM>n/EM>=10) were detected by immunohistochemistry. Results The amount of CD4EM>SUP>+ /SUP>/EM>T lymphocytes in the uterus of LPSinduced abortion mice was much higher (EM>P/EM><0.01) than that of the control mice, but there was no significant difference in the amount of CD4SUP>+ /SUP>T lymphocytes (EM>P/EM>>0.05). Also, the rate of CD4SUP>+/SUP> /CD8SUP>+/SUP> was increased significantly (P<0.01). When quercetin and bornyl acetate was used to prevent LPSinduced abortion, fewer CD4SUP>+/SUP> T cells were counted. The effect of quercetin combined with bornyl on antiLPSinduced abortion was more significant, and the rate of CD4SUP>+ /SUP>/

导出引用

王晓丹;史万玉;马爱团;姜国均;张建楼 ;翟向和;钟秀会. 槲皮素和乙酸龙脑酯对细菌脂多糖诱导流产孕小鼠子宫组织中CD4^{+/CD8^{+ T细胞的影响}}[J]. 解剖学报. 2008, 39(5): 734-737

INFLUENCE OF QUERCETIN AND BORNYL ACETATE ON CD4SUP>+ /SUP>/CD8SUP>+/SUP>T LYMPHOCYTES IN THE UTERUS FOLLOWING LPSINDUCED ABORTION IN PREGNANT MICE[J]. Acta Anatomica Sinica. 2008, 39(5): 734-737

中图分类号： S852.1