Objective Evaluation the effect of compound embryonic bovine liver extract tablets, ie An-Fa-Te (AFT) in treatment of nonalcoholic steatohepatitis (NASH) in rats by high frequency ultrasound. Methods Fifty-two SD rats were randomly divided into normal control groups, experimental groups and therapy groups. The two therapy groups were given the AFT from 8,12 weeks, respectively. The diameter and velocity of hepatic vein (HV) and ratio of hepatic pressure were measured using high frequency ultrasound. Results Fat degeneration commenced after 8 weeks of highfat diet. The liver enlarged, the edge of the liver became dull, the echo enhanced, and the vessels became indistinct. Those were more marked after 16 weeks. In pathological images, The simple fatty livers were observed in the model group at 8 weeks，and NASH in the model group of 16 weeks. The changes exhibited little in therapy groups. There were significant differences of ultrasound and pathological features between control /experimental and therapy group. Conclusions The AFT has effect in therapy for NASH in rats.