Objective To address the expression correlation of ribosomerelated genes in rat regeneration liver (RL) and those in liver tumor at transcriptional level. Methods Genes involved in ribosome biogenesis, assembly and function, as well as their expression changes in liver tumor, were obtained by online data collection and literature review, and their expression profiles in rat regenerating liver were detected by Rat Genome 230 2.0 array. Expression similarities and differences of the above genes were analyzed using statistical methods. Results A total of 75 genes were found to be RL-related. In regenerated liver and liver tumor, the expressions of 18 genes increased and 6 genes decreased, and no significant expression changes were found in 51 genes in liver tumor. Conclusion The expression profiles of the ribosomerelated genes in regenerated liver cells and liver tumor cells have both similarities and differences, and the former exhibit properties of more gradualness and complexity.