Objective The localization and morphology of somatostain(SS),serotonin(5-HT),gastrin(Gas) and vasoactive intestinal peptide(VIP) immunoreactive cells in Laiwu black goat digestive tract were studied. Methods Immunohistochemical SABC method was used. Results The morphology of endocrine cells in digestive tract was of multiplicity.The density of 5-HT cells was the highest in the colon,but not found in the esophagus,cardia gastric and cecum.The results showed that SS cells were distributed in the pylorus mostly,but not detected in the cardia,colon,cecum and rectum.Gas positive cells were the most in the duodenums,while in the esophagus and cardia was not discovered.In the cardia VIP cells were maximum,but in the esophagus,duodenums and ileum did not appear.Conclusion The location of the SS-,5-HT-,Gas- and VIP-positive cells mostly show up in the colon,the pylorus,the duodenums and the cardia respectively