P>Objective To explore the effects of heroin dependence on the gastrin(Gas), somatostatin(SS) positive cells in gastric antrum of rats and comprehend the possible functions of Gas, SS during heroin dependence. Methods Immunohistochemical SABC method and imagine analysis technique were employed. Results 1.Compared with the normal control group(NCG) and saline control group(SCG), the number of Gas positive cells increased (P<0.05), the intensity of staining stepped up gradually with the passage of time during dependence. The results of imagine analysis showed that the mean grey degree of Gas positive cells had the trend of descent, and it was lower than that in the NCG and SCG with the lowest degree on the 38th day. 2. The intensity of staining and the number of SS positive cells in gastric antrum in heroin dependence group(HDG) increased obviously compared with that in NCG and SCG(P<0.05) during heroin dependence, the mean grey degree stepped down remarkably than that in NCG and SCG.Conclusion The Gas, SS positive cells in gastric antrum of rats participate in the regulation course during heroin dependence by increasing the cell number and enhancing Gas and SS synthesis./P>