Objective To explore the mechanism of osteogenesis from statins through observing the effects of simvastatin on the VEGF expression of calvaria osteoblasts and its local influence on the mice calvaria. Methods Rat calvaria osteoblasts were harvested and cultured. Cells were treated with simvastatin for 24 hours. RT-PCR and immunocytology were performed to detect the expression of VEGF. Simvastatin was injected subcutaneously over the calvaria of mice for 4 days, the calvaria were pathologically examined. Results VEGF expression in rat calvaria osteoblasts was promoted by simvastain at both transcriptional and translational levels. In vitro the calvaria thickness and angiogenesis were increased by local administration of simvastatin. Conclusion Simvastatin can promote osteoblasts VEGF expression in vitro and mice calvaria angiogenesis and in