凝聚态Aβ 25～35可通过JNK/p38 MAPK途径诱导胎鼠皮层神经元Tau蛋白过度磷酸化

宋锦秋; 陈晓春; 张静; 黄天文; 曾育琦; 沈杰; 陈丽敏

解剖学报 ›› 2007, Vol. 38 ›› Issue (5) : 532-536.

论著

凝聚态Aβ _{25～35可通过JNK/p38 MAPK途径诱导胎鼠皮层神经元Tau蛋白过度磷酸化}

宋锦秋;陈晓春*; 张静;黄天文;曾育琦;沈杰;陈丽敏

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BETA AMYLOID PEPTIDE 25-35 INDUCES Tau PROTEIN HYPERPHOSPHORYLATION IN CORTICAL NEURONS THROUGH JNK/p38 MAPK PATH IN RAT EMBRYO

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Abstract

Objective To investigate the effect and the molecular mechanism of aggregated beta-amyloid peptide 25-35 (Aβ SUB>25-35/SUB>) on the level of Tau protein phosphorylation in rat embryo cortical neurons. Methods Western blotting and immunocytochemical stain were performed to observe the Tau protein phosphorylation and the expression of JNK/p38 MAPK Results The level of Tau protein phosphorylation in the sites of SerSUP>396/SUP>, SerSUP> 199/202/SUP> and ThrSUP>205/SUP> increased after Aβ SUB>25-35/SUB> of 20μmol/L was exposed to cortical neurons, meanwhile the level of JNK/p38 MAPK also increased after treatment with Aβ25-35 for 12 hours. Pretreatment with specific inhibitor of JNK/p38 MAPK markedly attenuated Tau pr

导出引用

宋锦秋;陈晓春;张静;黄天文;曾育琦;沈杰;陈丽敏. 凝聚态Aβ _{25～35可通过JNK/p38 MAPK途径诱导胎鼠皮层神经元Tau蛋白过度磷酸化}[J]. 解剖学报. 2007, 38(5): 532-536

BETA AMYLOID PEPTIDE 25-35 INDUCES Tau PROTEIN HYPERPHOSPHORYLATION IN CORTICAL NEURONS THROUGH JNK/p38 MAPK PATH IN RAT EMBRYO[J]. Acta Anatomica Sinica. 2007, 38(5): 532-536

中图分类号： R592