Objective To explore the effect mechanism of sympathetic nerve on early developing embryo of mice. Methods The model of sympathectomy mouse was established by 6-OHDA injected intraperitoneally.The early developing mice embryo and lymphocytes in uterus were observed using histology,immunohistochemistry and ELISA methods. Results In sympathectomy mouse,the number of embryo implantation was decrease to 64.4%,endometrial lamina propria and vascellum were shortfall.The numbers of CD4+T cell and CD8+T cell in sympathectomy mice were larger than ones in control groups, especially,the number of CD8+T cells at E3 and E5 differed highly (P<0.01).The quantity of IL-2 in sympathectomy mouse increased,and it was the highest at E5,increased to 3.6 times.The quantity of IL-4 was higher than that of control mouse only at E5,and the IL-2/IL-4 increased in sympathectomy mouse uterus.Conclusion Changes of uterus histology and CD4+,CD8+T cells and Th1/Th2 cells are the ones of effects of sympathetic nerve on early embryo development.