17-β雌二醇提高巯醇抗氧化物（酶）治疗脊髓损伤的作用 

边立功; 刘承杏; 李兴国; 马爱斌; 邹智荣; 李守民; 孙俊; 陆地 

doi:10.3969/j.issn.0529.1356.2010.02.004

解剖学报 ›› 2010, Vol. 41 ›› Issue (2) : 185-190. DOI: 10.3969/j.issn.0529.1356.2010.02.004

论著

17-β雌二醇提高巯醇抗氧化物（酶）治疗脊髓损伤的作用 

边立功^{1;刘承杏^{１;李兴国^{1;马爱斌^{2 ;邹智荣^{1 ;李守民^{1 ;孙俊^{1*; 陆地^{1* }}}}}}}}

作者信息 +

17-β estradiol reduces spinal cord injury of rats through raising thiol antioxidants

Author information +

文章历史 +

Abstract

Objective To examine the protective effects of 17-β estradiol on the experimental model of spinal cord injury (SCI) rats. Methods One hundred and eighty male Sprague Dawley (SD) rats, after Allen’s model, SD rats were divided into three groups: the sham group, the acute spinal cord injury (control groups) and the acute spinal cord injury supplying with 17-β estradiol treatment group. SCI was made by Allen’s weight dropping, impacting on the posteriors of spinal cord T10.The content of malonyldialdehyed (MDA), glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were determined by chromatometry. The expressions of Caspase-3 and Bcl-2 family in the injured spinal cord were detected by immunohistochemical staining. Results The BBB scores at each time point in 17-β estradiol treatment group were significantly higher than that in SCI group (EM>P/EM><0.05). The contents of GSH, SOD, GSH-Px and the expression of Bcl-2 protein at the majority of time point in 17-β estradiol treatment group were significantly higher than that in SCI group(EM>P/EM><0.05), however, the MDA, Caspase-3 and Bax were markedly decreased (EM>P/EM><0.05). Conclusions This study suggests that 17-β estradiol administration

导出引用

边立功;刘承杏;李兴国;马爱斌;邹智荣;李守民;孙俊;陆地 . 17-β雌二醇提高巯醇抗氧化物（酶）治疗脊髓损伤的作用 [J]. 解剖学报. 2010, 41(2): 185-190 https://doi.org/10.3969/j.issn.0529.1356.2010.02.004

17-β estradiol reduces spinal cord injury of rats through raising thiol antioxidants[J]. Acta Anatomica Sinica. 2010, 41(2): 185-190 https://doi.org/10.3969/j.issn.0529.1356.2010.02.004

中图分类号： R322.8