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p53-Ser392的磷酸化在肿瘤治疗中的作用
Role of phosphorylation of p53 at Ser392 in cancer therapy
磷酸化是p53转录后修饰最常见的方式, 但对p53-Ser392的磷酸化在肿瘤治疗中的作用及具体机制知之甚少。我们就p53-Ser392的磷酸化状态对野生型及突变型p53功能的影响、放疗化疗因素及蛋白激酶对p53-Ser392的磷酸化水平的调节和p53-Ser392的磷酸化研究意义进行了阐述。
Phosphorylation is the most common way of p53 post-translational modifications. However, gaps still exist in our knowledge regarding the role and mechanism of phosphorylation of p53 at Ser392 in carcinogenesis and cancer prevention. In the present study, we summarized the effect of phos-p53-Ser392 to wild-type and mutant p53, the regulation by DNA damage agents and protein kinase, and the significance of phosphorylation of p53-Ser392 in cancer treatment.
p53 / Ser392 / 磷酸化 / 肿瘤治疗 / 基因定点突变 / 免疫印迹法
p53 / Ser392 / Phosphorylation / Cancer therapy / Gene mutant / Western blotting
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