Olig对少突胶质细胞介导脱髓鞘大鼠髓鞘再生的影响

姚宏波 张萌 宫学武 孙丽慧*

doi:10.3969/j.issn.0529-1356.2014.01.007

解剖学报 ›› 2014, Vol. 45 ›› Issue (1) : 37-40. DOI: 10.3969/j.issn.0529-1356.2014.01.007

神经生物学

Olig对少突胶质细胞介导脱髓鞘大鼠髓鞘再生的影响

姚宏波¹张萌¹ 宫学武² 孙丽慧^1*

作者信息 +

Effects of remyelination of Olig on oligodendrocyte mediated demyelination in the rat

YAO Hong-bo¹ ZHANG Meng¹GONG Xue-wu² SUN Li-hui ^1*

Author information +

文章历史 +

摘要

目的探讨Olig在少突胶质细胞介导的脱髓鞘大鼠髓鞘再生中的作用。方法 40只健康Wistar大鼠，随机分成正常组、模型对照组、模型组、实验组，用形态学观察和免疫组织化学检测Olig1和Olig2的表达。结果正常组Olig1位于少突胶质细胞的胞质，模型组胞核表达明显增多，实验组Oligl又重新转移至胞质；正常组Olig2表达位于胞核，模型组中有少量表达于胞质。结论在Olig1和Olig2同时缺失时，导致全脑不能形成少突胶质细胞，严重影响髓鞘的再生。

Abstract

Objective To investigate the role of oligodendrocytes mediated demyelination in the rat about Olig in myelin regeneration. Methods Forty healthy Wistar rats were randomly divided into normal group, model control group, model group and research group. Morphological observation and Immuno- histochemistry detection expression of Olig1 and Olig2 were performed. Results Olig1 was located the cytoplasm of oligodendrocytes in normal group, nuclear expression was increased significantly in model group, and Olig1 was retransferred to the cytoplasm in the research group. Expression of Olig2 was located in the nucleus in the normal group. A few of Olig2 were expressed in the cytoplasm in the model group. Conclusion The brain may not be able to generate oligodendrocytes when Oligl and Olig2 are deficient, which is affect of the myelin regeneration.

导出引用

姚宏波张萌宫学武孙丽慧*. Olig对少突胶质细胞介导脱髓鞘大鼠髓鞘再生的影响[J]. 解剖学报. 2014, 45(1): 37-40 https://doi.org/10.3969/j.issn.0529-1356.2014.01.007

YAO Hong-bo ZHANG Meng GONG Xue-wu SUN Li-hui*. Effects of remyelination of Olig on oligodendrocyte mediated demyelination in the rat[J]. Acta Anatomica Sinica. 2014, 45(1): 37-40 https://doi.org/10.3969/j.issn.0529-1356.2014.01.007

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