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循环纤维细胞与器官纤维化
Circulating fibrocytes and organic fibrosis
器官纤维化的发生与细胞外基质（ECM）的过度沉积有关。过去认为组织固有（肌）成纤维细胞是细胞外基质生成的主要细胞，近年来的研究则发现，血液中骨髓来源的循环纤维细胞在纤维化疾病的产生和发展过程起到了重要的作用。活化的循环纤维细胞不仅自身可分泌细胞外基质参与纤维化进程，也能通过分化成为（肌）成纤维细胞来发挥生理性和病理性的纤维化作用。循环纤维细胞具有多种生物学功能，能直接分泌各种细胞因子或促进相关因子的生成来促进纤维化进程。同时，循环纤维细胞的生成、转移、分化及其致纤维化作用也受到了不同的细胞因子和信号通路的调控。我们主要对于近年来循环纤维细胞与器官纤维化的研究进展予以综述。
Fibrosis of organs is related with over-accumulation of extracellular matrix(ECM). It is widely acknowledged that (myo)fibroblasts lead to the formation of extracellular matrix. Recent studies confirm that marrow-derived circulating fiobrocytes play important roles in the formation and process of fibrosis. Activated circulating fibrocytes not only secrete extracellular matrix that is essential for the process of fibrosis, but also
differentiated into (myo)fibroblasts leading to fibrosis, either physiologically or pathologically. Circulating fibrocytes have special characteristics and various bio-functions, and secrete various cytokines to accelerate the fibrosis. The formation, migration, differentiation and fibrosis-promoting function are also regulated by various cytokines and pathways. This article aims to review the latest development in circulating fibrocytes and organic fibrosis.
Circulating fibrocyte / Organic fibrosis / Signaling pathways
［1］Gao ChF, Lu LG.［M］.Shanghai: Sahnghai Science and Technology, 2004. (in Chinese)
高春芳, 陆伦根. ［M］. 上海：上海科学技术出版社, 2004.
［2］Li YD, Niu JZh, Wang JF, et al.［J］. Acta Anatomica Sinica, 2007, 38(2): 168-172. (in Chinese)
李亚东，朱建昭，王继锋，等.［J］. 解剖学报，2007，38（2）：168-172.
［3］Bucala R, Spiegel LA, Chesney J,et al.［J］. Mol Med, 1994, 1(1):71-81.
［4］Shao DD, Suresh R, Vakil V, et al.［J］. Leukoc Biol, 2008, 83(6):1323-1333.
［5］Curnow SJ, Fairclough M, Schmutz C, et al. ［J］. PLoS One, 2010, 5(3):e9730.
［6］Niedermeier M, Reich B, Rodriguez Gomez M, et al. ［J］. Proc Natl Acad Sci USA, 2009, 106(42):17892-17897.
［7］Wada T,Sakai N, Sakai Y, et al.［J］.Clin Exp Nephrol, 2011, 15(1):8-13.
［8］Broekema M, Harmsen MC, van Luyn MJ, et al. ［J］. J Am Soc Nephrol, 2007, 18(1):165-175.
［9］Chen G, Lin SC, Chen J, et al.［J］. J Am Soc Nephrol, 2011, 22(10):1876-1886.
［10］Andersson-Sj?land A, Nihlberg K, Eriksson L, et al. ［J］. Respir Res, 2011, 9,12(1):76.
［11］ Li YD, Niu JZh, Wang JF, et al.［J］. Acta Anatomica Sinica, 2007,38(2):168-172. (in Chinese)
李亚东, 牛建昭,王继峰,等. ［J］. 解剖学报, 2007,38(2):168-172.
［12］Hong KM, Belperio JA, Keane MP, et al.［J］. J Biol Chem, 2007, 282(31):22910-22920.
［13］Choi YH, Burdick MD, Strieter RM.［J］. Int J Biochem Cell Biol, 2010, 42(5):662-671.
［14］Ekert JE, Murray LA, Das AM, et al.［J］. Fibrogenesis Tissue Repair, 2011, 4(1):23.
［15］Moore BB, Murray L, Das A, et al.［J］. Am J Respir Cell Mol Biol, 2006, 35(2):175-181.
［16］Xu J, Lin SC, Chen J, et al.［J］. Am J Physiol Heart Circ Physiol, 2011, 301(2):H538-547.
［17］Moore BB, Kolodsick JE, Thannickal VJ, et al.［J］. Am J Pathol, 2005, 166(3):675-684.
［18］Mehrad B, Burdick MD, Zisman DA, et al.［J］. Biochem Biophys Res, 2007, 353(1):104-108.
［19］Andersson-Sj?land A, de Alba CG, Nihlberg K, et al.［J］. Int J Biochem Cell Biol, 2008, 40(10):2129-2140.
［20］Lama VN, Phan SH. ［J］. Proc Am Thorac Soc, 2006, 3(4):373-376.
［21］Phillips RJ, Burdick MD, Hong K, et al.［J］. J Clin Invest, 2004, 114(3):438-446.
［22］Field JJ, Burdick MD, DeBaun MR, et al.［J］. PLoS One, 2012, 7(3):e33702.
［23］Strieter RM, Keeley EC, Hughes MA, et al.［J］. J Leukoc Biol, 2009, 86(5):1111-1118.
［24］Chu PY, Mariani J, Finch S, et al.［J］. Am J Pathol, 2010, 176(4):1735-1742.
［25］Sakai N, Wada T, Yokoyama H, et al.［J］. Proc Natl Acad Sci USA, 2006, 103(38):14098-14103.
［26］Wada T, Sakai N, Matsushima K, et al.［J］. Kidney Int, 2007, 72(3):269-273.
［27］Abe R, Donnelly SC, Peng T, et al.［J］. J Immunol, 2001, 166(12):7556-7562.
［28］Grieb G, Steffens G, Pallua N, et al.［J］. Int Rev Cell Mol Biol, 2011, 291:1-19.
［29］Quan TE, Cowper S, Wu SP, et al.［J］. Int J Biochem Cell Biol, 2004, 36(4):598-606.
［30］Garcia-de-Alba C, Becerril C, Ruiz V, et al.［J］. Am J Respir Crit Care Med,2010, 182(9):1144-1152.
［31］Hartlapp I, Abe R, Saeed RW, et al.［J］. FASEB J, 2001, 15(12):2215-2224.
［32］Bellini A, Mattoli S.［J］. Lab Invest, 2007, 87(9):858-870.
［33］Herzoga EL, Bucala R.［J］. Experimental Hematol, 2010, 38(7): 548-556.
［34］Wang CH, Huang CD, Lin HC, et al.［J］. Am J Respir Crit Care Med, 2008, 178(6):583-591.
［35］Schmidt M, Sun G, Stacey MA, et al.［J］. J Immunol, 2003, 171(1):380-389.
［36］Nihlberg K, Larsen K, Hultg?rdh-Nilsson A, et al.［J］. Respir Res, 2006, 7(1): 50.
［37］Saunders R, Siddigui S, Kaur D, et al.［J］. J Allergy Clin Immunol, 2009, 123(2):376-384.
［38］Fujiwara A, Kobayashi H, Masuya M, et al.［J］. Respirology, 2012, 17(4):693-698.
［39］Sakai N, Wada T, Matsushima K, et al.［J］. J Hypertens, 2008, 26(4):780-790.
［40］Ishida Y, Kimura A, Takayasu T, et al.［J］. Int J Legal Med, 2009, 123(4):299-304.
［41］Oh MH, Oh SY, Yu J, et al.［J］. J Immunol, 2011, 186(12):7232-7242.
［42］Forbes SJ, Russo FP, Rey V, et al.［J］. Gastroenterology, 2004, 126(4):955-963.
［43］Quan TE, Cowper S, Wu SP, et al.［J］. Int J Biochem Cell Biol, 2004, 36(4):598-606.
［44］Forbes SJ, Russo FP, Rey V, et al.［J］. Gastroenterology, 2004, 126(4):955-963.
［45］Jarcuska P, Janicko M, Veselíny E, et al.［J］. Clin Chim Acta, 2010, 11(15-16):1009-1017.
［46］Haudek SB, Xia Y, Huebener P, et al.［J］. Proc Natl Acad Sci USA, 2006, 103(48):18284-18289.
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