N-甲基-D-天门冬氨酸受体2A亚单位在SD成年雄性大鼠不同脑区的分布

毕文杰 肖莉 郑翔*

解剖学报 ›› 2013, Vol. 44 ›› Issue (4) : 456-462.

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解剖学报 ›› 2013, Vol. 44 ›› Issue (4) : 456-462. DOI: 10.3969/j.issn.0529-1356.2013.04.003
神经生物学

N-甲基-D-天门冬氨酸受体2A亚单位在SD成年雄性大鼠不同脑区的分布

  • 毕文杰 肖莉1  郑翔2*
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N-methyl-D-aspartate receptor 2A expression intensity in brain regions of adult male SD rats

  • BI Wen-jie XIAO Li ZHENG Xiang 2*
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摘要

目的 获取大鼠脑部的N-甲基-D-天门冬氨酸受体2A(NMDAR 2A)表达强度分布的数据。方法 通过免疫组织化学染色和图像分析,对成年雄性SD大鼠(n=6)不同脑区的NMDAR 2A表达进行检测。结果 得到大鼠全脑各主要结构NMDAR 2A 表达强度的数据,并绘制图谱。结论
获得的NMDAR 2A表达图谱可为原位检测鼠 脑NMDAR 2A的实验提供参考。

Abstract

Objective N-methyl-D-aspartate receptor (NMDAR) is an important excitatory receptor within the central nervous system. Its 2A subunit is a critical functional subunit. There is no comprehensive data about NMDAR 2A expression intensity
in rat brain. Methods In this experiment, we detected NMDAR 2A expression in the brain of adult male SD rat (n=6) with immunohistochemistry staining and image analysis. Results We drew the expression intensity atlas of rat brain based on the
immunohistochemical staining intensity. Conclusion These data can provide a reference for in situ detection of NMDAR 2A in related experiments.

关键词

/ N-甲基-D-天门冬氨酸受体2A / 免疫组织化学 / 大鼠

Key words

Brain / N-methyl-D-aspartate receptor 2A / Immunohistochemistry / Rat

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毕文杰 肖莉 郑翔*. N-甲基-D-天门冬氨酸受体2A亚单位在SD成年雄性大鼠不同脑区的分布[J]. 解剖学报. 2013, 44(4): 456-462 https://doi.org/10.3969/j.issn.0529-1356.2013.04.003
BI Wen-jie XIAO Li ZHENG Xiang*. N-methyl-D-aspartate receptor 2A expression intensity in brain regions of adult male SD rats[J]. Acta Anatomica Sinica. 2013, 44(4): 456-462 https://doi.org/10.3969/j.issn.0529-1356.2013.04.003
中图分类号: R322.8-3   

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基金

成都医学院校基金课题(CYZ09-006)


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