三阴性乳腺癌干细胞微球体的治疗

赵乐 梁晨 李倩 裴晓华*

doi:10.3969/j.issn.0529-1356.2013.03.029

解剖学报 ›› 2013, Vol. 44 ›› Issue (3) : 437-440. DOI: 10.3969/j.issn.0529-1356.2013.03.029

综述

三阴性乳腺癌干细胞微球体的治疗

赵乐¹梁晨²李倩²裴晓华³

作者信息 +

Therapeutic research on triple negative breast cancer stem cell mammospheres

ZHAO Le¹ LIANG Chen² LI Qian² PEI Xiao-hua ^3*

Author information +

文章历史 +

摘要

三阴性乳腺癌(TNBC)是指雌激素受体(ER)、孕激素受体(PR)及人类表皮生长因子受体2 (HER-2)均为阴性的乳腺癌。TNBC恶性程度高，
侵袭性强，易远处转移，预后差，对内分泌治疗及靶向治疗的效果均欠佳，是临床治疗的难点。近几年研究发现，三阴性乳腺癌的发生、发展
很可能与其中的乳腺癌干细胞有关，乳腺癌干细胞微球体培养是一种收集干细胞的方法，被广泛用于三阴性乳腺癌的干细胞研究。

Abstract

Triple negative breast cancer（TNBC）is characterized by estrogen receptor(ER) negative, progesteronereceptor(PR)
negative, and human epidermal growth factorreceptor-2(HER-2) negative histochemical staining. TNBC has the features of high
malignant degree, strong invasion, prone to distant metastasis and poor prognosis. The endocrine therapy and targeted therapy
are generally not satisfied. Finding a effective treatment is a key point in clinical research. Recent studies have shown that
occur rence and development progress of TNBC may be related to breast cancer stem cells. Mammosphere culture is a very good
method of collection of breast cancer stem cells, and is used very widely in stem cells of TNBC.

导出引用

赵乐梁晨李倩裴晓华*. 三阴性乳腺癌干细胞微球体的治疗[J]. 解剖学报. 2013, 44(3): 437-440 https://doi.org/10.3969/j.issn.0529-1356.2013.03.029

ZHAO Le LIANG Chen LI Qian PEI Xiao-hua*. Therapeutic research on triple negative breast cancer stem cell mammospheres[J]. Acta Anatomica Sinica. 2013, 44(3): 437-440 https://doi.org/10.3969/j.issn.0529-1356.2013.03.029

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