孕期酒精暴露对子鼠视网膜双极细胞和水平细胞发育的影响

刘曦; 王永毅; 姚焕玲; 赵博; 于亚东; 胡馨; 邓锦波

doi:10.3969/j.issn.0529-1356.2012.04.014

解剖学报 ›› 2012, Vol. 43 ›› Issue (4) : 518-523. DOI: 10.3969/j.issn.0529-1356.2012.04.014

组织学胚胎学发育生物学

孕期酒精暴露对子鼠视网膜双极细胞和水平细胞发育的影响

刘曦^{1,2; 王永毅^{2; 姚焕玲^{1; 赵博^{2; 于亚东^{2; 胡馨^{2; 邓锦波^1*}}}}}}

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Prenatal alcohol exposure affects development of retinal bipolar and horizontal cells in mice

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Abstract

Objective To investigate effects of alcohol exposure during pregnancy on retinal bipolar and horizontal cells in filial mice.Methods The animal model of prenatal alcohol exposure was made. The development of bipolar cells and horizontal cells at prenatal days 7, 14 and 30 was investigated with immunofluorescent labeling and DiI scattering techniques. Results In all age groups, the density of the bipolar cells was significantly lower in the experiment groups than in the control groups. The dendritic field and the number of branches of horizontal cells were significantly lower in the experimental group than in the control group ( P <0.01). Conclusion Alcohol exposure during pregnancy affects development of retinal bipolar and horizontal cells in mice.

导出引用

刘曦;王永毅;姚焕玲;赵博;于亚东;胡馨;邓锦波. 孕期酒精暴露对子鼠视网膜双极细胞和水平细胞发育的影响[J]. 解剖学报. 2012, 43(4): 518-523 https://doi.org/10.3969/j.issn.0529-1356.2012.04.014

Prenatal alcohol exposure affects development of retinal bipolar and horizontal cells in mice[J]. Acta Anatomica Sinica. 2012, 43(4): 518-523 https://doi.org/10.3969/j.issn.0529-1356.2012.04.014

中图分类号： R743.3