Objective To investigate the correlation of the basic fibroblast growth factor (bFGF) gene 5 single nucleotide polymorphisms(SNP) and bone mineral density(BMD) in Guangxi Zhuang nationality men. Methods A case-control study was carried out on 147 osteopenia patients and 154 matched controls. Inclusion criteria were at the age of 41 to 78, Zhuang nationality,living in Baise more than 10 years, and no history of taking drugs affecting bone metabolism. Exclusion criteria included secondary osteoporosis, any disease affecting bone mineral density or consanguinity. Genotypes for adiponectin gene 5 locis (rs308379、rs12644427、rs3789138、rs308442 and rs3747676) polymorphism were determined by Multiplex SNaPshot. Broadband ultrasound attenuation (BUA) for the right leg calcaneal was measured by French production of Osteospace dry ultrasound bone densitometer. Results rs308379、rs12644427、rs3789138、rs308442 and rs3747676 polymorphisms were met with HardyWeinberg equilibrium ( EM>P/EM> >0.05). Five locis genotype frequencies in the normal group and the osteopenia group were met with Hardy-Weinberg equilibrium (EM> P/EM> >0.05). There was no significant difference in the genotype distributions of five locis polymorphism between LBM group and control group ( P >0.05). Multivariate Logistic regression analyses revealed only rs308442 polymorphism remained significantly associated with low bone mass(LBM) ( EM>P/EM> <0.05). The subjects with the combined TA genotype had higher risk of LBM compared with those with the TT genotype( EM>OR/EM> =1.831,95% EM>CI/EM> :1.075-3.116,EM> P/EM> =0.026).Polymorphism of rs308442 was independently correlated with LBM at the calcaneal in Baise Zhuang femail population. Conclusion bFGF gene intron 1 rs308442 polymorphism and BMD in Baise Prefecture Zhuang men have some relevance. The presence of the T allele A may dominantly increase the risk of osteopenia. TT genotype has a protective effect of BMD.The data also suggest th