甲醛对机体整体内源性代谢产物的影响

徐浩; 崔立然; 张玲

doi:10.3969/j.issn.0529-1356.2012.03.022

解剖学报 ›› 2012, Vol. 43 ›› Issue (3) : 412-416. DOI: 10.3969/j.issn.0529-1356.2012.03.022

组织学胚胎学发育生物学

甲醛对机体整体内源性代谢产物的影响

徐浩^{1; 崔立然^{2* ; 张玲²}}

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Effects of formaldehyde on the endogenous metabolism in the body

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Abstract

Objective To investigate effects of formaldehyde on endogenous metabolites of urine. Methods The urinary samples of the formaldehyde contact group and control group were analyzed by UPLC –Q-TOF/MS, combined with principal component analysis(PCA). The overall disease pattern of the metabolic network was established based on metabolic profiles in different groups. Results The different trajectory of urine was visually noted from metabolic profiles between 2 groups. Metabolomics appeared to be suitable for toxicity studies of formaldehyde, and a biomarker structure was identified. Conclusion The science connotation of the toxicity of formaldehyde may be elucidated by Metabonomics, according to metabolites variance in certain disease

导出引用

徐浩;崔立然 ;张玲. 甲醛对机体整体内源性代谢产物的影响[J]. 解剖学报. 2012, 43(3): 412-416 https://doi.org/10.3969/j.issn.0529-1356.2012.03.022

Effects of formaldehyde on the endogenous metabolism in the body[J]. Acta Anatomica Sinica. 2012, 43(3): 412-416 https://doi.org/10.3969/j.issn.0529-1356.2012.03.022

中图分类号： R322.33