DARPP-32在大鼠全脑的定位分布

王伟文SUB&gt;; SUB&gt; 廖晓阳; 吴俞宪; 王庆松; 林杭; 肖莉; 陈良为; 饶志仁

doi:10.3969/j.issn.0529-1356.2011.06.004

解剖学报 ›› 2011, Vol. 42 ›› Issue (6) : 737-740. DOI: 10.3969/j.issn.0529-1356.2011.06.004

神经生物学

DARPP-32在大鼠全脑的定位分布

王伟文^{1*SUB>;/SUB> 廖晓阳^{2 ; 吴俞宪^{1;^{王庆松^{1 ;林杭^{1 ;肖莉^{1 ;陈良为^{3 ;饶志仁³}}}}}}}}

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Immunohistochemical localization of DARPP-32, a dopamine and cyclic-AMP-regulated phosphoprotein, in the rat brain

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Abstract

Objective To study the distribution of DARPP-32 in the rat brain. BR>Methods Immunohistochemical staining techniques were applied to study the localization of DARPP-32 in neurons of the rat brain. Results The strong immunoreactivity for DARPP-32 was localized primarily in the basal ganglia and the anterior olfactory area, involving neuronal cell bodies or dendrites in the nucleus accumbens, caudate putamen, amygdaloid nucleus and fibers throughout the globus pallidus, ventral pallidum and pars reticulate of the substantia nigra. The moderate to weak immunoractivity for DARPP-32 was observed in red nucleus, septofimbrial nucleus, purkinje cells in cerebellum, medial habenula nucleus, cortex and hippocampus. DARPP-32 was present in the cytoplasm, cytomembrane and cell nucleus of labeled neuronal somata and dendrites. Conclusion DARPP-32 is widely distributed in the rat brain. It is primarily present in the neurons, which receive a dopamine input and contain dense of the D1 receptor. DARPP-32 may play an important role in dopaminoceptive neurons. BR>

导出引用

王伟文; 廖晓阳 ;吴俞宪; 王庆松;林杭;肖莉 ;陈良为;饶志仁. DARPP-32在大鼠全脑的定位分布[J]. 解剖学报. 2011, 42(6): 737-740 https://doi.org/10.3969/j.issn.0529-1356.2011.06.004

Immunohistochemical localization of DARPP-32, a dopamine and cyclic-AMP-regulated phosphoprotein, in the rat brain[J]. Acta Anatomica Sinica. 2011, 42(6): 737-740 https://doi.org/10.3969/j.issn.0529-1356.2011.06.004

中图分类号： R322