Objective To investigate the optimization technique for computer aided measurement and provide anatomical data for the retrograde acetabulum anterior column screw percutaneously. Methods Forty pelvic model data were collected by CT scan and then reconstructed in 3-D. The optimization objective function for the single screw fixation was set, the optimal placement was accumulated under constraint conditions. The new anatomical reference marks were designed after the statistics were analyzed. Results The percutaneous retrograde anterior column acetabular screws entrance point lies in the superior ramus of pubis, pubic tubercle and the midpoint iliopubic uplift of the obturator crest. The out point is between the anterior superior iliac spine from top to bottom notch and above the midpoint of the greater sciatic notch. The connection of the two points is the longitudinal axis of the anterior column acetabular, which is parallel with the arcuate line. Its direction connected with the anterior inferior iliac spine was (42.84 ± 2.61) ° and with Iliac was (31.96 ± 2.58) °. Length of the screw in bone was (101.12 ± 7.28) mm. Conclusion The automatic optimization technique for computer aided measurement is very efficient and has many advantages over the conventional manual dissection methods, it is convenient to design an anatomical reference landmark system and formulate a surgical plan