小鼠肾脏发生发育中BAX的表达

宋小峰; 任昊; 陈雪; 翟效月

doi:10.3969/j.issn.0529-1356.2011.04.024

解剖学报 ›› 2011, Vol. 42 ›› Issue (4) : 548-551. DOI: 10.3969/j.issn.0529-1356.2011.04.024

组织学胚胎学与发育生物学

小鼠肾脏发生发育中BAX的表达

宋小峰^{1,2;任昊^{1;陈雪^{1; 翟效月^1*}}}

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Expression of BAX during the development of mouse kidney

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Abstract

Objective To explore the expression of BAX during mouse kidney development. Methods Fifty-four mice from embryonic day 16, 18 and postnatal day 1, 3, 5, 7, 14, 21 were chosen to investigate the expression of BAX on epoxy sections of different development phases of mouse kidney with immunohistochemistry technique and stereological methods. Results The immunohistochemical positive staining of BAX was mainly observed in proximal tubules. During development, the expressive position of BAX gradually moved from deep to middle cortex, and finally was located on the superficial cortex. The numerical area density of BAX gradually increased from E16d to P3d, then descend, and turned to increase again at postnatal day 7. Conclusion During the development of kidney, the expression of BAX closely relates to the growth of proximal tubules, and may impact the proximal tubules in surviving, differentiating and maturing.

导出引用

宋小峰;任昊;陈雪;翟效月. 小鼠肾脏发生发育中BAX的表达[J]. 解剖学报. 2011, 42(4): 548-551 https://doi.org/10.3969/j.issn.0529-1356.2011.04.024

Expression of BAX during the development of mouse kidney[J]. Acta Anatomica Sinica. 2011, 42(4): 548-551 https://doi.org/10.3969/j.issn.0529-1356.2011.04.024

中图分类号： R329.1