N-乙酰-L-色氨酸具有对新生鼠脑缺血/缺氧损伤的保护作用 

蒋吉英; 姜桂兰; 李磊; 赵金岭; 史才兴; 于树娜; 齐安东

doi:10.3969/j.issn.0529-1356.2011.04.004

解剖学报 ›› 2011, Vol. 42 ›› Issue (4) : 451-455. DOI: 10.3969/j.issn.0529-1356.2011.04.004

神经生物学

N-乙酰-L-色氨酸具有对新生鼠脑缺血/缺氧损伤的保护作用 

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Protective effect of N-acetyl-L-tryptophan in cerebral ischemia/hypoxia injury

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Abstract

Objective To investigate the possible neuroprotective effects of N-acetyl-L-tryptophan（L-NAT） in cerebral ischemia/hypoxia injury. Methods The ischemia/hypoxia injury models were made in 90 pups of seven days old gerbil.The death of neurons was evaluated by Fluoro-Jade B（FJB）staining and the activations of Caspase-9 and Caspase-3 were evaluated by immunofluorescent staining and Western blotting. Results Our results showed that L-NAT treatment decreased the number of FJB positive cells after middle cerebral artery occlusion in mice. And L-NAT also inhibited the expressions of Caspase-3 and Caspase-9. Conclusion Our work demonstrated that L-NAT had

导出引用

蒋吉英;姜桂兰 ;李磊;赵金岭;史才兴;于树娜;齐安东. N-乙酰-L-色氨酸具有对新生鼠脑缺血/缺氧损伤的保护作用 [J]. 解剖学报. 2011, 42(4): 451-455 https://doi.org/10.3969/j.issn.0529-1356.2011.04.004

Protective effect of N-acetyl-L-tryptophan in cerebral ischemia/hypoxia injury[J]. Acta Anatomica Sinica. 2011, 42(4): 451-455 https://doi.org/10.3969/j.issn.0529-1356.2011.04.004

中图分类号： R743.3