血管内皮生长因子、Eph受体酪氨酸激酶A2、基质金属蛋白酶-2和-9在卵巢癌血管生成拟态中的作用

王立; 王俊艳; 赵秀兰; 赵楠; 张丹芳; 孙保存

doi:10.3969/j.issn.0529-1356.2011.03.017

解剖学报 ›› 2011, Vol. 42 ›› Issue (3) : 378-383. DOI: 10.3969/j.issn.0529-1356.2011.03.017

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血管内皮生长因子、Eph受体酪氨酸激酶A2、基质金属蛋白酶-2和-9在卵巢癌血管生成拟态中的作用

王立^{1 ;王俊艳^{1* ;赵秀兰^{2;赵楠^{2 ;张丹芳^{2;孙保存^2}}}}}

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Effects of vascular endothelial growth factor，Eph receptor A2, matrix metalloproteinase-2 and -9 in ovarian carcinoma vasculogenic mimicry

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Abstract

Objective To investigate the effect of vascular endothelial growth factor (VEGF), Eph receptor A2(EphA2), matrix metalloproteinases(MMP)-2 and MMP-9 in ovarian carcinoma vasculogenic mimicry(VM). Methods Totally 84 ovarian carcinoma specimens with complete clinical and prognostic data were collected, and using CD31 and PAS double staining to confirm if vasculogenic mimicry exists in the ovarian carcinoma specimens. Immunohistochemical method was used to detect VEGF, EphA2, MMP-2 and MMP-9, examining the results of the immunohistochemical method according to the dye index. Results VEGF, EphA2 and MMP-9 in ovarian carcinoma specimens had significant differences between the VM group (36/84) and non-VM group (48/84), the expression in the VM group showed significantly higher than that in non-VM group. But the expression of MMP-2 between the two groups was not statistically significant. BR> Conclusion Vasculogenic mimicry and endothelium-derived angiogenesis are co-existed in ovarian carcinoma, VEGF, EphA2 and MMP-9 play important roles in vasculogenic mimicry. Detecting VEGF, EphA2 and MMP-9 can be used to evaluate the prognosis of ovarian carainoma. BR>

导出引用

王立;王俊艳;赵秀兰;赵楠;张丹芳;孙保存. 血管内皮生长因子、Eph受体酪氨酸激酶A2、基质金属蛋白酶-2和-9在卵巢癌血管生成拟态中的作用[J]. 解剖学报. 2011, 42(3): 378-383 https://doi.org/10.3969/j.issn.0529-1356.2011.03.017

Effects of vascular endothelial growth factor，Eph receptor A2, matrix metalloproteinase-2 and -9 in ovarian carcinoma vasculogenic mimicry[J]. Acta Anatomica Sinica. 2011, 42(3): 378-383 https://doi.org/10.3969/j.issn.0529-1356.2011.03.017

中图分类号： R730