Wnt2b/β-catenin/C-myc信号途径在小鼠胚胎心脏中的时空表达

孙莉; 丁玉龙; 陈筠; 侯巧燕

doi:10.3969/j.issn.0529-1356.2011.02.019

解剖学报 ›› 2011, Vol. 42 ›› Issue (2) : 236-240. DOI: 10.3969/j.issn.0529-1356.2011.02.019

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Wnt2b/β-catenin/C-myc信号途径在小鼠胚胎心脏中的时空表达

孙莉^{1* ;丁玉龙^{1;陈筠^{1;侯巧燕²}}}

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Temporal and spatial expression of Wnt2b/β-catenin/C-myc signaling pathway in the mouse embryonic heart

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Abstract

Objective To investigate the temporal and spatial expression of Wnt2b/β-catenin/C-myc signaling pathway in mouse embryonic heart. Methods The mouse embryonic hearts taken from gravidity 10 days(G10d), G12.5d, G15d, G17d, G18.5d, and postnatal day(P0d) were used. Immunohistochemistry, RT\|PCR and Western blotting were performed to detect the expressions of Wnt2b, β-catenin and C-myc during different periods of mouse embryonic heart development. Results With the progress of the embryonic heart development, the expressions of Wnt2b, β-catenin and C-myc at the mRNA and protein levels were decreasing gradually, and the mRNA expression of Wnt2b,β-catenin and C-myc showed that they were interrelated statistically (EM>P/EM><0.05).Conclusion These results suggest that Wnt2b/β-catenin/C-myc signaling pathway play important roles in regulating the development of the embryonic heart. And it can predict that C-my

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孙莉;丁玉龙;陈筠;侯巧燕. Wnt2b/β-catenin/C-myc信号途径在小鼠胚胎心脏中的时空表达[J]. 解剖学报. 2011, 42(2): 236-240 https://doi.org/10.3969/j.issn.0529-1356.2011.02.019

Temporal and spatial expression of Wnt2b/β-catenin/C-myc signaling pathway in the mouse embryonic heart[J]. Acta Anatomica Sinica. 2011, 42(2): 236-240 https://doi.org/10.3969/j.issn.0529-1356.2011.02.019

中图分类号： R329.1