DNA甲基转移酶1和组蛋白去乙酰化酶1在子宫内膜异位症在位内膜的表达

王水英; 胡燕军; 周彩云; 黄荷凤

doi:10.3969/j.issn.0529-1356.2011.02.018

解剖学报 ›› 2011, Vol. 42 ›› Issue (2) : 232-235. DOI: 10.3969/j.issn.0529-1356.2011.02.018

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DNA甲基转移酶1和组蛋白去乙酰化酶1在子宫内膜异位症在位内膜的表达

王水英^{1;胡燕军^{2;周彩云^{2;黄荷凤^2*}}}

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Expression of DNA methyltransferase　1 and histone deacetylase 1 in endometrium of women with endometriosis

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Abstract

Objective To investigate the alteration in the expression of DNA methyltransferase 1(DNMT1) and histone deacetylase 1(HDAC1) in endometrium from women with endometriosis and to explore the effects of both DNMT1 and HDAC1 on the endometriosis. Methods DNMT1 was localized with immunohistochemistry，DNMT1 and HDAC1 was quantified with Western blotting in the endometrium of 38 premenopausal women (18 with endometriosis and 20 without endometriosis). Results DNMT1 was predominantly located in the nuclei of glandular epithelial cells and stromal cells. The intensities of the DNMT1 immunohistochemical staining were significantly higher in the women endometrium with endometriosis than those without endometriosis(EM>P/EM><0.01）. DNMT1 and HDAC1 protein levels in the endometrium of women with endometriosis were significantly higher than those without endometriosis throughout the menstrual cycle（EM>P/EM><0.05）. There was a positive correlation between endometrial DNMT1 and HDAC1 levels in the endometriosis（EM>P/EM><0.05）.Conclusion High expression of DNMT1 and HDAC1 in the endometrium sug

导出引用

王水英;胡燕军;周彩云;黄荷凤. DNA甲基转移酶1和组蛋白去乙酰化酶1在子宫内膜异位症在位内膜的表达[J]. 解剖学报. 2011, 42(2): 232-235 https://doi.org/10.3969/j.issn.0529-1356.2011.02.018

Expression of DNA methyltransferase　1 and histone deacetylase 1 in endometrium of women with endometriosis[J]. Acta Anatomica Sinica. 2011, 42(2): 232-235 https://doi.org/10.3969/j.issn.0529-1356.2011.02.018

中图分类号： R711.71