罗格列酮对OLETF大鼠肺组织TGF-β1/Smad信号转导途径的影响

赵伟; 姜丽娟; 朱梦瑜; 刘佳; 张雅静; 陈晓琴; 张宏

doi:10.3969/j.issn.0529-1356.2011.02.017

解剖学报 ›› 2011, Vol. 42 ›› Issue (2) : 226-231. DOI: 10.3969/j.issn.0529-1356.2011.02.017

论著

罗格列酮对OLETF大鼠肺组织TGF-β1/Smad信号转导途径的影响

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Effects of rosiglitazone treatment on TGF-β1/Smad signaling pathways in Otsuka Long-Evans Tokushima Fatty rat lungs

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Abstract

Objective To approach the effects of rosiglitazone treatment on transforming growth factor-β1/Smad(TGF-β1/Smad) signaling pathways in Otsuka Long-Evans Tokushima Fatty(OLETF) rats. Methods Experimental rats were divided into three groups: OLETF group, rosiglitazone-treated group(OLETF/L group) and Long Evans Tokushima Otsuka rats (LETO group) as control, 8 rats in each group. The expression of TGF-β1, Smad2, Smad3, Smad7, fibronectin(FN), and collagen type Ⅲ in rat lungs were examined by immunohistochemistry. Results The expressions of TGF-β1, Smad2, Smad3, FN and collagen type Ⅲ increased in OLETF rat lungs than those of LETO rats(EM>P/EM><0.01), while the expression of Smad7 decreased in OLETF group(EM>P/EM><0.01). The expressions of TGF-β1, Smad2, Smad3, FN and collagen type Ⅲ decreased in OLETF/L group than those of the OLETF group(EM>P/EM><0.01), and the expression of Smad7 increased in OLETF/L group(EM>P/EM><0.01). Conclusion

导出引用

赵伟;姜丽娟;朱梦瑜;刘佳;张雅静;陈晓琴;张宏. 罗格列酮对OLETF大鼠肺组织TGF-β1/Smad信号转导途径的影响[J]. 解剖学报. 2011, 42(2): 226-231 https://doi.org/10.3969/j.issn.0529-1356.2011.02.017

Effects of rosiglitazone treatment on TGF-β1/Smad signaling pathways in Otsuka Long-Evans Tokushima Fatty rat lungs[J]. Acta Anatomica Sinica. 2011, 42(2): 226-231 https://doi.org/10.3969/j.issn.0529-1356.2011.02.017

中图分类号： R587.1