Objective To evaluate the cerebral glucose metabolism of Alzheimer’s disease(AD) model mouse by SUP>18/SUP>F-FDG and MicroPET，and develop an imaging technique to evaluate AD drugs therapeutic effect on animal models. Methods The 9 mice of control group, APPSUP>swe/SUP>/PSΔE9 doubletransgenic group and aricept treatment group［2 mg/(kgI>&#/I>8226;d)］ were injected SUP>18/SUP>F-FDG by peritoneal cavity and scanned by Micro-PET. The glucose uptake value of cerebrum，frontal cortex and temporal cortex region of interest(ROI) were analysed by IRW software. Results The images of SUP>18/SUP>F-FDG and Micro-PET could be used to detect the cerebral glucose metabolism of AD mouse model. We found that the cerebral glucose metabolism was decreased in the APPSUP>swe/SUP>/PSΔE9 doubletransgenic mice, which was consistent with phenotype of the human AD. Aricept treatment improved the cerebral glucose metabolism of AD disease model mice. Conclusion The imaging analysis using SUP>18/SUP>F-FDG an