β-连环蛋白与卵巢癌转移的相关性及调节机制

胡军; 邵淑娟; 董岩; 宋阳; 宫琳琳; 杨佩满

doi:10.3969/j.issn.0529-1356.2010.05.014

解剖学报 ›› 2010, Vol. 41 ›› Issue (5) : 709-713. DOI: 10.3969/j.issn.0529-1356.2010.05.014

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β-连环蛋白与卵巢癌转移的相关性及调节机制

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Associativity and mechanism of β-catenin with ovarian cancer metastasis

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Abstract

Objective To investigate associativity and mechanism of β-catenin with ovarian cancer metastasis. Methods The different expressions of β-catenin in high and low metastatic human ovarian serous cystadenocarcinoma cells（HO-8910PM and HO-8910） were detected by immunofluorescence staining, Western blotting and RT-PCR analysis. To further investigate the regulated mechanism of β-catenin with ovarian cancer metastasis, low metastatic human ovarian serous cystadenocarcinoma HO-8910 cells were treated by hepatocyte growth factor(HGF). The expression change of β-catenin in HO-8910 cells was investigated by the same technology mentioned above. Then, HO-8910 cells invasion and migration abilities were assessed by Transwell chambers and scratch wound migration assay. Results The expression of β-catenin was significantly lower in HO-8910PM cells than that in HO-8910 cells (P<0.05). HGF could downregulate the expression of β-catenin in HO-8910 cells (P<0.05) and enhance cell invasion (P<0.05) and migration. Conclusion The lower expression of β-catenin may be correlated with invasion and migration pot

导出引用

胡军;邵淑娟;董岩;宋阳;宫琳琳;杨佩满. β-连环蛋白与卵巢癌转移的相关性及调节机制[J]. 解剖学报. 2010, 41(5): 709-713 https://doi.org/10.3969/j.issn.0529-1356.2010.05.014

Associativity and mechanism of β-catenin with ovarian cancer metastasis[J]. Acta Anatomica Sinica. 2010, 41(5): 709-713 https://doi.org/10.3969/j.issn.0529-1356.2010.05.014

中图分类号： R 737.31