睡眠剥夺后大鼠皮质、海马和杏仁核微管相关蛋白-2及神经丝蛋白的表达变化

王景涛; 邱洪斌; 田国忠; 扈青云; 徐辉; 王柏新; 李廷利

doi:10.3969/j.issn.0529-1356.2010.03.006

解剖学报 ›› 2010, Vol. 41 ›› Issue (03) : 358-361. DOI: 10.3969/j.issn.0529-1356.2010.03.006

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睡眠剥夺后大鼠皮质、海马和杏仁核微管相关蛋白-2及神经丝蛋白的表达变化

王景涛^{1,2; 邱洪斌^{1; 田国忠^{1* ; 扈青云^{1; 徐辉^{1; 王柏新^{1;李廷利^2}}}}}}

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Expression of microtubule-associated protein-2 and neurofilament-200 in rat brain after sleep deprivation

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Abstract

P>Objective To study the expression of microtubule-associated protein-2(MAP-2) and neurofilament-200(NF-200) in cortex, hippocampus and amygdaloid body of rat after sleep deprivation(SD). Methods SD model was made by modified multiple platform method（MMPM）, rats were divided into sleep deprivation group(SD),tank control group(TC), cage control group(CC). The sleep deprivation group included seven time-length groups (sleep deprivation 6 hours,12 hours,1 day,2 days,3 days,5 days and 7 days). Five rats were assigned to each group. The expression of MAP-2 and NF-200 were detected by immunohistochemical method. Results At the 5th day and 7th day, we found that the density of MAP-2 and NF-200 positive neuron decreased in cortex, CA1,CA2,CA3,dentate gyrus and amygdaloid body（P0.05，P0.01). Conclusio

导出引用

王景涛;邱洪斌;田国忠;扈青云;徐辉;王柏新;李廷利. 睡眠剥夺后大鼠皮质、海马和杏仁核微管相关蛋白-2及神经丝蛋白的表达变化[J]. 解剖学报. 2010, 41(03): 358-361 https://doi.org/10.3969/j.issn.0529-1356.2010.03.006

Expression of microtubule-associated protein-2 and neurofilament-200 in rat brain after sleep deprivation[J]. Acta Anatomica Sinica. 2010, 41(03): 358-361 https://doi.org/10.3969/j.issn.0529-1356.2010.03.006

中图分类号： P>Q189/P>