谷氨酸受体与γ-氨基丁酸A受体在APPswe转基因小鼠海马结构中的表达

范文娟; 席艳; 程维杰; 牛艳丽; 于东明; 邓锦波

doi:10.3969/j.issn.0529-1356.2010.03.001

解剖学报 ›› 2010, Vol. 41 ›› Issue (03) : 333-338. DOI: 10.3969/j.issn.0529-1356.2010.03.001

论著

谷氨酸受体与γ-氨基丁酸_{A受体在APPswe转基因小鼠海马结构中的表达}

范文娟 ;席艳 ;程维杰; 牛艳丽 ;于东明; 邓锦波*

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Expression of glutamate receptors and GABASUB>A/SUB> receptors in the hippocampus of APPswe transgenic mice

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Abstract

Objective In order to understand the relationship between the receptors of excitatory and inhibitory neurotransmitter and Alzheimer disease(AD), the expression of glutamate receptors and GABASUB>Aα1-/SUB>SUB>6 /SUB>in the CA3 region of hippocampus of APPswe transgenic mice was investigated. Methods These mice from postnatal day 0 to postnatal day 360 were used in the study with the N-methyl-D-asprtate receptor 1(NMDAR1), GluR2/3 and GABASUB>Aα1-6/SUB> immunofluorescent stainings. In the meantime, Western blotting was carried out to detect the expressions of NMDAR1 and GABASUB>Aα1-6/SUB> in the hippocampus as well. Results The numbers of NMDAR1,GluR2/3 and GABASUB>Aα1-6 /SUB> positive neurons increased obviously after P7, in both wild type and transgenic mice, with the peaks at P30 However, in aged animals(P360), NMDAR1 and GluR2/3 lost in transgenic mice with statistically significant difference ( P< 005), comparing with wild type, but the alterations of GABASUB>Aα1-6/SUB> receptor was not obvious (EM>P/EM>>0.05) between wild type and transgenic mice. Conclusion The study showed that glutamate receptors in hippocampu

导出引用

范文娟;席艳;程维杰;牛艳丽;于东明;邓锦波. 谷氨酸受体与γ-氨基丁酸_{A受体在APPswe转基因小鼠海马结构中的表达}[J]. 解剖学报. 2010, 41(03): 333-338 https://doi.org/10.3969/j.issn.0529-1356.2010.03.001

Expression of glutamate receptors and GABASUB>A/SUB> receptors in the hippocampus of APPswe transgenic mice[J]. Acta Anatomica Sinica. 2010, 41(03): 333-338 https://doi.org/10.3969/j.issn.0529-1356.2010.03.001

中图分类号： R322.8