过氧化物酶体增殖因子激活受体γ、环氧合酶-2在子宫内膜癌中的表达及超微结构定位

卞海燕; 李媛媛; 吴洪娟; 刘雨清

doi:10.3969/j.issn.0529-1356.2010.01.022

解剖学报 ›› 2010, Vol. 41 ›› Issue (1) : 114-118. DOI: 10.3969/j.issn.0529-1356.2010.01.022

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过氧化物酶体增殖因子激活受体γ、环氧合酶-2在子宫内膜癌中的表达及超微结构定位

卞海燕^{1;李媛媛^{2;吴洪娟^{2;刘雨清^1*}}}

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Expression and ultrastructure location of PPAR-γ and COX-2 in endometrial carcinoma

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Abstract

Objective To investigate the development and prognosis of peroxisome proliferators-activated receptor-γ(PPAR-γ) and cyclooxygenase-2(COX-2) in endometrial carcinoma. Methods The electron microscopic immunohistochemical technique was used to observe the ultrastructure location of COX-2 protein labeled by colloidal gold in the endometrial carcinoma. Results 1.There were negative immunohistochemical staining signals of PPAR-γ in both the normal endometrium and hyperplasia endometrium, whereas, was positive staining in the endometrial carcinoma; 2.The intensities of the COX-2 immunohistochemical staining were significantly statistical difference among the normal endometrium, the hyperplasia endometriu and the endometrial carcinoma(EM>P/EM><0.01); 3. The COX-2 labelled by colloidal gold granules was observed in the endoplasmic reticulum, nuclear membrane and nuclei in the endometrial carcinoma. Conclusion Both PPAR-γ and the COX-2 might play an important role in the development

导出引用

卞海燕;李媛媛;吴洪娟;刘雨清. 过氧化物酶体增殖因子激活受体γ、环氧合酶-2在子宫内膜癌中的表达及超微结构定位[J]. 解剖学报. 2010, 41(1): 114-118 https://doi.org/10.3969/j.issn.0529-1356.2010.01.022

Expression and ultrastructure location of PPAR-γ and COX-2 in endometrial carcinoma[J]. Acta Anatomica Sinica. 2010, 41(1): 114-118 https://doi.org/10.3969/j.issn.0529-1356.2010.01.022

中图分类号： R737.33