转化生长因子β受体在小鼠胚胎心流出道的表达

刘慧霞; 景宜馨; 郭健津; 张紫燕; 李海荣; 杨艳萍; 张涛; 景雅

doi:10.3969/j.issn.0529-1356.2009.06.021

解剖学报 ›› 2009, Vol. 40 ›› Issue (6) : 954-957. DOI: 10.3969/j.issn.0529-1356.2009.06.021

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转化生长因子β受体在小鼠胚胎心流出道的表达

刘慧霞^{1;景宜馨^{2; 郭健津^{2 ;张紫燕^{2 ;李海荣^{1 ;杨艳萍^{1 ;张涛^{1;景雅^1*}}}}}}}

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Expression of transforming growth factor-β receptors in the outflow tract of mouse embryonic heart

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Abstract

Objective To investigate the spatiotemporal expression patterns of transforming growth factor-β(TGF-β) receptors type Ⅰ and type Ⅱ and their relationships with development of outflow tract(OFT) in mouse embryonic heart. Methods Serial sections of mouse embryos from embryonic day 9 (E9d) to embryonic day 14 (E14d) were stained using PAP immunohistochemical methods. Results Expressions of TGF-β receptors type Ⅰ (TGF-βRⅠ) and type II(TGF-βRⅡ) in the myocardial wall of OFT started at E10d, reached the reflection with splanchnic epithelium on the dorsal wall of the pericardial cavity at E11d. At E12d, expression intensity of TGF-βRⅠ and TGF-βRⅡ in myocardium increased to its highest level, and TGF-βRⅡ positive mesenchymal cells in OFT ridges could be detected. After E13d the staining intensity of TGF-βRⅠ and TGF-βRⅡ decreased rapidly，

导出引用

刘慧霞;景宜馨;郭健津;张紫燕;李海荣;杨艳萍;张涛;景雅. 转化生长因子β受体在小鼠胚胎心流出道的表达[J]. 解剖学报. 2009, 40(6): 954-957 https://doi.org/10.3969/j.issn.0529-1356.2009.06.021

Expression of transforming growth factor-β receptors in the outflow tract of mouse embryonic heart[J]. Acta Anatomica Sinica. 2009, 40(6): 954-957 https://doi.org/10.3969/j.issn.0529-1356.2009.06.021

中图分类号： Q132