肝细胞核因子-1α和肝细胞核因子-4α在人肝细胞癌中的表达及意义

郑洁; 董承伟; 蒋吉英; 张皓云; 魏德全; 丁洁

doi:10.3969/j.issn.0529-1356.2009.06.017

解剖学报 ›› 2009, Vol. 40 ›› Issue (6) : 933-937. DOI: 10.3969/j.issn.0529-1356.2009.06.017

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肝细胞核因子-1α和肝细胞核因子-4α在人肝细胞癌中的表达及意义

郑洁^{1 ;董承伟^{2 ;蒋吉英^{3*; 张皓云^{3 ;魏德全^{3 ;丁洁³}}}}}

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Expressions of hepatocyte nuclear factor -1α and hepatocyte nuclear factor -4α in human hepatocellular carcinoma

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Abstract

Objective To investigate the expression of hepatocyte nuclear factor-1α (HNF-1α) and hepatocyte nuclear factor-4α (HNF-4α) in human hepatocellular carcinoma (HCC) and explore the function of HNF-1α and HNF-4α during HCC carcinogenesis and development. Methods Twenty-six specimens of hepatocellular carcinoma were collected. The expressions of HNF-1α and HNF-4α in HCC tissues and adjacent non-cancerous tissues were detected by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry staining. Results The mRNA levels of HNF-1α and HNF-4α were significantly lower in HCC tissues than that in adjacent non-cancerous tissues (0.818±0.371 vs. 0.383±0.102 for HNF-1α, P0.05; 0.846±0.384 vs. 0.397±0.105 for HNF-4α, P0.05）.The positive rates of HNF-1α and HNF-4α protein were significantly lower in HCC tissues than in adjacent non-c

导出引用

郑洁;董承伟;蒋吉英;张皓云 ;魏德全;丁洁. 肝细胞核因子-1α和肝细胞核因子-4α在人肝细胞癌中的表达及意义[J]. 解剖学报. 2009, 40(6): 933-937 https://doi.org/10.3969/j.issn.0529-1356.2009.06.017

Expressions of hepatocyte nuclear factor -1α and hepatocyte nuclear factor -4α in human hepatocellular carcinoma[J]. Acta Anatomica Sinica. 2009, 40(6): 933-937 https://doi.org/10.3969/j.issn.0529-1356.2009.06.017

中图分类号： R730.2