细胞色素C和Bax在创伤后应激障碍大鼠海马神经元的表达及意义

李晓明; 韩芳; 石玉秀

doi:10.3969/j.issn.0529-1356.2009.06.004

解剖学报 ›› 2009, Vol. 40 ›› Issue (6) : 869-872. DOI: 10.3969/j.issn.0529-1356.2009.06.004

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细胞色素C和Bax在创伤后应激障碍大鼠海马神经元的表达及意义

李晓明; 韩芳; 石玉秀*

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Expression and significance of cytochrome C and Bax in hippocampus of posttraumatic stress disorder rat

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Abstract

Objective To observe the expression of cytochrome C （Cyt C）and apoptosis-related gene Bax in hippocampus of posttraumatic stress disorder（PTSD）rats in order to investigate their effects and relationships. Methods Sixty male Wistar rats were used in the present study. The single-prolonged stress（SPS）-method was carried out to set up the rat PTSD models. There were six groups：after SPS 1，4，7，14，28 days groups and control group. The expression of Cyt C and Bax proteins were detected with immunohistochemistry, double immunofluorescence, confocal laser scanning microscopy and Western blotting. Results The expression of Cyt C peaked at 4 days and maintained higher level at 7 days after SPS. At 7 days after SPS, strong immunoreactivity of Bax was noticed,At 14 days after SPS, the expression of Bax was down-regulated and then gradually decreased. Conclusion Bax is

导出引用

李晓明;韩芳;石玉秀. 细胞色素C和Bax在创伤后应激障碍大鼠海马神经元的表达及意义[J]. 解剖学报. 2009, 40(6): 869-872 https://doi.org/10.3969/j.issn.0529-1356.2009.06.004

Expression and significance of cytochrome C and Bax in hippocampus of posttraumatic stress disorder rat[J]. Acta Anatomica Sinica. 2009, 40(6): 869-872 https://doi.org/10.3969/j.issn.0529-1356.2009.06.004

中图分类号： R332.81