14-3-3 ζ与β连接素在人T1期非小细胞肺癌中的表达及意义

臧东钰; 李晓明; 张林

doi:10.3969/j.issn.0529-1356.2009.05.027

解剖学报 ›› 2009, Vol. 40 ›› Issue (5) : 826-829. DOI: 10.3969/j.issn.0529-1356.2009.05.027

论著

14-3-3 ζ与β连接素在人T_{1期非小细胞肺癌中的表达及意义}

臧东钰^{1; 李晓明^{2 ;张林^1*}}

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Expressions of 14-3-3 ζ and β-catenin proteins in human TSUB>1/SUB> non-small cell lung cancer and the significance

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Abstract

Objective To observe the expressions of 14-3-3 ζ and β-catenin in human TSUB>1/SUB> nonsmall cell lung cancer(NSCLC), and to investigate the relationship between the expressions of 14-3-3 ζ and β-catenin and progression and invasion in NSCLC. Methods The expressions of 14-3-3 ζ and β-catenin were detected by immunohistochemistry, double fluorescent, laser scanning confocal microscopy and Western blotting in NSCLC and normal lung. Results Upregulation of 14-3-3 ζ was observed significantly in stage TSUB>1/SUB> NSCLC in contrast to that in normal lung. The increased 14-3-3 ζ protein level was correlated with differentiation degree and lymph node metastasis, but it was no correlation with histological type. Decreased expression of β-catenin was observed in NSCLC in contrast to that in normal lung. The expression of β-catenin was positively related to differentiation degree and was negatively related to the lymph node metastasis, and there was no relationship between β-catenin expression and histological type. Conclusion 14-3-3 ζ a

导出引用

臧东钰;李晓明;张林. 14-3-3 ζ与β连接素在人T_{1期非小细胞肺癌中的表达及意义}[J]. 解剖学报. 2009, 40(5): 826-829 https://doi.org/10.3969/j.issn.0529-1356.2009.05.027

Expressions of 14-3-3 ζ and β-catenin proteins in human TSUB>1/SUB> non-small cell lung cancer and the significance[J]. Acta Anatomica Sinica. 2009, 40(5): 826-829 https://doi.org/10.3969/j.issn.0529-1356.2009.05.027

中图分类号： R734.2