槲皮素和乙酸龙脑酯对细菌脂多糖诱导流产小鼠子宫组织IFN-γ/IL-4和巨噬细胞的影响

王晓丹; 马爱团; 史万玉; 姜国均; 钟秀会

doi:10.3969/j.issn.0529-1356.2009.04.023

解剖学报 ›› 2009, Vol. 40 ›› Issue (4) : 637-641. DOI: 10.3969/j.issn.0529-1356.2009.04.023

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槲皮素和乙酸龙脑酯对细菌脂多糖诱导流产小鼠子宫组织IFN-γ/IL-4和巨噬细胞的影响

王晓丹^{1，2; 马爱团^{2 ;史万玉^{1;姜国均^{2 ;钟秀会^1*}}}}

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Influence of quercetin and bornyl acetate on ratio of IFN-γ/IL-4 and macrophages in uteri of LPS-induced abortion mice

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Abstract

Objective To investigate significance of interferon-γ/interleukin-4(IFN-γ/IL-4) and macrophages in uterus in early embryo loss (or resorption), and to elucidate the anti-abortive effect and the immunological modulation at maternal-fetal interface with quercetin and bornvl acetate. Methods Lipopolysaccharide (LPS)（0.10μg/mouse）was injected via tail vein in order to induce abortion in 7-day-gestation mice which received quercetin and bornvl acetate at days 4-7 of gestation. Levels of IFN-γ and IL-4 in uterus lysate supernatant were measured using enzyme-linked immuno-absorbent assay (ELISA), and uterine macrophages of each group (EM>n/EM>=10) were detected by immunohistochemistry. Results The amount of macrophages was much higher in the uteri of LPSinduced abortion mice than that in control mice. The abortion rate of mouse declined to certain level. The therapy of quercetin combined with bornyl acetate reversed LPS-induced abortion. Conclusion The increase of IFN-γ/IL-4 and the amount of macrophages in the LPStreated mouse uterus is associated with the embryo loss, and que

导出引用

王晓丹;马爱团 ;史万玉;姜国均;钟秀会. 槲皮素和乙酸龙脑酯对细菌脂多糖诱导流产小鼠子宫组织IFN-γ/IL-4和巨噬细胞的影响[J]. 解剖学报. 2009, 40(4): 637-641 https://doi.org/10.3969/j.issn.0529-1356.2009.04.023

Influence of quercetin and bornyl acetate on ratio of IFN-γ/IL-4 and macrophages in uteri of LPS-induced abortion mice[J]. Acta Anatomica Sinica. 2009, 40(4): 637-641 https://doi.org/10.3969/j.issn.0529-1356.2009.04.023

中图分类号： S853.7