组蛋白去乙酰化酶1在子宫内膜异位症中的表达及意义

王水英; 罗琼; 胡燕军; 黄荷凤 

doi:10.3969/j.issn.0529-1356.2009.03.031

解剖学报 ›› 2009, Vol. 40 ›› Issue (3) : 500-502. DOI: 10.3969/j.issn.0529-1356.2009.03.031

论著

组蛋白去乙酰化酶1在子宫内膜异位症中的表达及意义

王水英^{1,2; 罗琼^{1 ;胡燕军^{1 ;黄荷凤^{1* }}}}

作者信息 +

Expression and significance of histone deacetylase 1 in endometriosis

Author information +

文章历史 +

Abstract

Objective To investigate the expression of histone deacetylase1 (HDAC1) in the eutopic and ectopic endometrium of women with endometriosis. Methods The expression of HDAC1 in the eutopic and ectopic endometrium of 20 cases of women with endometriosis, and the expression of HDAC1 in the endometrium of 20 cases with hysteromyoma were mesured by immunohistochemical technique and Western blotting. Results HDAC1 was located in the nuclei of epithelial and stromal cells. The expression level of HDAC1 in eutopic endometrium was significantly higher than that in the control group (EM>P/EM><0.01). In Western blotting, semiquantitative analysis showed that the relative expression of HDAC1 protein in eutopic and ectopic endometrium were significantly higher than that in the control group (2.67±0.69；2.55±1.36 vs 1.63±0.93, EM>P/EM><0.01，EM>P/EM><0.05). But there was no significant difference between eutopic and ectopic endometrium (P>0.05). Conclusion The higher expression of HDAC1 in eutopic and ectopic endometrium with endometriosis indicates that it may play an import

导出引用

王水英;罗琼;胡燕军 ;黄荷凤 . 组蛋白去乙酰化酶1在子宫内膜异位症中的表达及意义[J]. 解剖学报. 2009, 40(3): 500-502 https://doi.org/10.3969/j.issn.0529-1356.2009.03.031

Expression and significance of histone deacetylase 1 in endometriosis[J]. Acta Anatomica Sinica. 2009, 40(3): 500-502 https://doi.org/10.3969/j.issn.0529-1356.2009.03.031

中图分类号： R711