β淀粉样蛋白25～35急性给药和慢性孵育对神经元Ca2+非依赖性的K+电流作用的比较

张鹏俊; 杨小荣; 董斌; 孙萍; 王永; 张策  

doi:10.3969/j.issn.0529-1356.2009.03.007

解剖学报 ›› 2009, Vol. 40 ›› Issue (3) : 379-384. DOI: 10.3969/j.issn.0529-1356.2009.03.007

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β淀粉样蛋白25～35急性给药和慢性孵育对神经元Ca^{2+非依赖性的K^{+电流作用的比较}}

张鹏俊^{1 ;杨小荣^{1; 董斌^{1;孙萍^{1 ; 王永^{2 ; 张策^{1* }}}}}}

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Abstract

P> Objective To study the different effects between the acute administration and chronic exposure of βamyloidpeptide 2535(Aβ25-35) on the Ca2+independent K+ currents in rat hippocampal and cerebral cortical neurons. Methods After different applications (acute administration and chronic exposure) of Aβ25-35 in rat hippocampal or cerebral cortical neurons, the Ca2+independent K+ currents were recorded by wholecell patch clamp technique and the cell viability was detected by Calcein-AM staining. BR> Results The amplitudes of the Ca SUP>2+/SUP>independent K+ currents were significantly decreased by acute administration to AβSUB>25-35/SUB> in acute isolation of hippocampal neurons (EM>n/EM>=11) while the amplitudes were marke

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张鹏俊;杨小荣;董斌;孙萍;王永;张策 . β淀粉样蛋白25～35急性给药和慢性孵育对神经元Ca^{2+非依赖性的K^{+电流作用的比较}}[J]. 解剖学报. 2009, 40(3): 379-384 https://doi.org/10.3969/j.issn.0529-1356.2009.03.007

Comparison of the effects of acute administration and chronic exposure of βamyloidpeptide 25-35 on the Ca SUP>2+/SUP>-independent KSUP>+/SUP> currents in rat  BR>hippocampal and cerebral cortical neurons BR>[J]. Acta Anatomica Sinica. 2009, 40(3): 379-384 https://doi.org/10.3969/j.issn.0529-1356.2009.03.007

中图分类号： R338