低剂量棉酚与甾体激素联合用药抗男性生育协同作用

常青; 邵金辉; 许增禄; 张成侠; 钱晓菁

doi:10.3969/j.issn.0529-1356.2009.02.029

解剖学报 ›› 2009, Vol. 40 ›› Issue (2) : 312-316. DOI: 10.3969/j.issn.0529-1356.2009.02.029

论著

低剂量棉酚与甾体激素联合用药抗男性生育协同作用

常青 ;邵金辉; 许增禄*; 张成侠; 钱晓菁

作者信息 +

Synergistic effect of combined regimen of low-dose gossypol with steroid hormones on male antifertility

Author information +

文章历史 +

Abstract

Objective To study the synergistic effect on male antifertility of a combined regimen of lowdoes gossypol with steroid hormones. Methods Adult male rats were divided randomly BR> into four groups: group GH, rats were fed orally with GA ［12.5mg/(kgI>&#/I>8226;d)］ and DSG ［0.125mg/(kgI>&#/I>8226;d)］/E ［0.025mg/(kgI>&#/I>8226;d)］/TU［100mg/L(kgI>&#/I>8226;d)］; group G, a single does of GA ［12.5mg/(kgI>&#/I>8226;d)］ was given; group H, DSG ［0.125mg/(kgI>&#/I>8226;d)］/E［0.025mg/(kgI>&#/I>8226;d)］/TU［100mg/(kgI>&#/I>8226;d)］ were administered; group C, rats only received vehicle (1% methyl cellulose). The testis and epididymis were removed at 4,6 and 8 week for counting sperm number，sperm motility and stereological changes of testis tissue. Results Low-dose gossypol with steroid hormones did not have a synergistic effect on reducing testicular weight，sperm production or stereological parameters. However, they did have a synergistic effect on reducing epididymal sperm number and sperm motilit

导出引用

常青;邵金辉;许增禄;张成侠;钱晓菁. 低剂量棉酚与甾体激素联合用药抗男性生育协同作用[J]. 解剖学报. 2009, 40(2): 312-316 https://doi.org/10.3969/j.issn.0529-1356.2009.02.029

Synergistic effect of combined regimen of low-dose gossypol with steroid hormones on male antifertility[J]. Acta Anatomica Sinica. 2009, 40(2): 312-316 https://doi.org/10.3969/j.issn.0529-1356.2009.02.029

中图分类号： R979.2