兔下颌骨牵张成骨中HIF-1α和EM&gt;c-fos/EM&gt;的表达及其相关性

赵翚; 谢志坚; 何剑锋; 葛巍立; 林坚; 胡济安

doi:10.3969/j.issn.0529-1356.2009.02.026

解剖学报 ›› 2009, Vol. 40 ›› Issue (2) : 299-302. DOI: 10.3969/j.issn.0529-1356.2009.02.026

论著

兔下颌骨牵张成骨中HIF-1α和EM>c-fos/EM>的表达及其相关性

赵翚^{１;谢志坚^{2*;何剑锋^{2 ;葛巍立^{2 ;林坚^{1 ;胡济安²}}}}}

作者信息 +

Expressions of HIF-1α，EM>c-fos/EM> and their relationships in mandibular distraction osteogenesis in rabbits

Author information +

文章历史 +

Abstract

P>Objective To investigate the expressions of HIF-1α, c-fos and their relationships in mandibular distraction osteogenesis in rabbits. Methods To establish an animal model of mandibular distraction osteogenesis with 25 healthy adult rabbits.The expressions of HIF-1α and EM>c-fos/EM> were detected by ultrasensitive SP immunohistochemical methods. Results Immunohistochemical studies showed that the HIF-1α was expressed strongly in distraction zone at the 8th days after distraction. One week after consolidation, the EM>c/EM>-EM>fos/EM> was expressed strongly in the distraction zone at the 4 th day, 8th days after distraction, and 1 week after consolidation.Both apparently expressed apparently higher than those in the distraction zone of at the third and fifth week after consolidation. HIF-1α and EM>c-fos/EM> were mainly expressed in fibroblasts, osteoblasts and osteocytes. Conclusion In mandibular distraction osteogenesis of rabbits, there is a marked relati

导出引用

赵翚;谢志坚;何剑锋;葛巍立;林坚;胡济安. 兔下颌骨牵张成骨中HIF-1α和EM>c-fos/EM>的表达及其相关性[J]. 解剖学报. 2009, 40(2): 299-302 https://doi.org/10.3969/j.issn.0529-1356.2009.02.026

Expressions of HIF-1α，EM>c-fos/EM> and their relationships in mandibular distraction osteogenesis in rabbits[J]. Acta Anatomica Sinica. 2009, 40(2): 299-302 https://doi.org/10.3969/j.issn.0529-1356.2009.02.026

中图分类号： R332