血管紧张素Ⅱ对发育期小鼠肾小体细胞增殖的影响

李晓明; 薄双玲; 郭敏

doi:10.3969/j.issn.0529-1356.2009.02.025

解剖学报 ›› 2009, Vol. 40 ›› Issue (2) : 295-298. DOI: 10.3969/j.issn.0529-1356.2009.02.025

论著

血管紧张素Ⅱ对发育期小鼠肾小体细胞增殖的影响

李晓明 ;薄双玲; 郭敏*

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Effect of angiotensin Ⅱ on cell proliferation of renal corpuscle in mouse kidney development

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Abstract

Objective To observe the EM>in vitro/EM> effects of angiotensin Ⅱ on cell proliferation of the renal corpuscle in embryonic day 12 mouse kidneys. Methods Pregant female mice(embryonic day 12)were randomly divided into six groups:control group and groups which were induced by different angiotensin Ⅱ(10SUP>-9/SUP>mol/L 10SUP>-5/SUP>mol/L) concentrations. The kidney tissues were cultured for two,four or six days.The proliferating cell nuclear antigen (PCNA) expression was detected by immunohistochemistry and immunofluorescence techniques. Results AngiotensinⅡ promoted cell proliferation of the renal corpuscle. To some extent, the proliferative activity tended to enhance with increasing of the angiotensinⅡ concentration, and the effect had a positive relation to induced time. The proliferative activity at the 4th day was stronger than that at the 2nd day.Conclusion AngiotensinⅡ can promote cell proliferation in the

导出引用

李晓明;薄双玲;郭敏. 血管紧张素Ⅱ对发育期小鼠肾小体细胞增殖的影响[J]. 解剖学报. 2009, 40(2): 295-298 https://doi.org/10.3969/j.issn.0529-1356.2009.02.025

Effect of angiotensin Ⅱ on cell proliferation of renal corpuscle in mouse kidney development[J]. Acta Anatomica Sinica. 2009, 40(2): 295-298 https://doi.org/10.3969/j.issn.0529-1356.2009.02.025

中图分类号： R329