橙皮苷抗抑郁作用的研究进展(英文)

SHEN  Yan-yang; ZHANG  Yong; HUANG  Min; LIU  Xue-hong*

doi:10.16098/j.issn.0529-1356.2026.04.015

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解剖学报 ›› 2026, Vol. 57 ›› Issue (4) : 507-516. DOI: 10.16098/j.issn.0529-1356.2026.04.015

综述

橙皮苷抗抑郁作用的研究进展(英文)

沈艳阳张泳黄旻刘学红^*

作者信息 +

Research progress on the antidepressant effect of hesperidin

SHEN Yan-yang, ZHANG Yong, HUANG Min, LIU Xue-hong^*

Author information +

文章历史 +

摘要

抑郁障碍是一种病因和发病机制复杂的心理疾病。近年来，神经营养假说受到了广泛关注。脑源性神经营养因子（BDNF）对中枢神经系统（CNS）至关重要。它们特异性地结合酪氨酸激酶受体B（TrkB），激活其下游信号通路。橙皮苷是一种类黄酮化合物，具有多种生物效应，包括抗氧化、抗炎、抗癌、神经保护和抗抑郁特性。有趣的是，橙皮苷可以激活并上调BDNF水平，这在抗炎、抗氧化、神经元存活和突触可塑性方面发挥着重要作用。本综述探讨了橙皮苷的抗抑郁功效，强调其通过激活关键分子通路［如, BDNF/TrkB信号通路、核因子κB（NF-κB）、下丘脑-垂体-肾上腺（HPA）轴和单胺氧化酶A/B（MAO-A/MAO-B）］来缓解抑郁症状的作用。显然，橙皮苷的多重抗抑郁作用和良好的安全性凸显了其在天然治疗药物领域的巨大潜力。

Abstract

Depressive disorder is a mental disorder with complex etiology and pathogenesis. The neurotrophic hypothesis has recently garnered significant attention. Brain-derived neurotrophic factor (BDNF) is crucial for the central nervous system (CNS). They specifically bind to the tyrosine kinase receptor B (TrkB), activating its downstream signaling pathways. Hesperidin, a flavonoid compound, exhibits a range of biological effects, including antioxidant, anti-inflammatory, anticancer, neuroprotective, and antidepressant properties. Interestingly, hesperidin can activate and upregulate BDNF levels, which plays a significant role in anti-inflammation, antioxidation, neuronal survival, and synaptic plasticity. This review explores the antidepressant efficacy of hesperidin, highlighting its role in mitigating depressive symptoms through the activation of critical molecular pathways such as BDNF/TrkB signaling, nuclear factor-kappa B (NF-κB), the hypothalamic-pituitary-adrenal (HPA) axis, and monoamine oxidase A/B (MAO-A/MAO-B). Clearly, the multifaceted antidepressant effects and favorable safety profile of hesperidin highlight its significant potential in the field of natural therapeutic agents.

导出引用

沈艳阳张泳黄旻刘学红. 橙皮苷抗抑郁作用的研究进展(英文)[J]. 解剖学报. 2026, 57(4): 507-516 https://doi.org/10.16098/j.issn.0529-1356.2026.04.015

SHEN Yan-yang, ZHANG Yong, HUANG Min, LIU Xue-hong. Research progress on the antidepressant effect of hesperidin[J]. Acta Anatomica Sinica. 2026, 57(4): 507-516 https://doi.org/10.16098/j.issn.0529-1356.2026.04.015

中图分类号： R322.8 R749 R459.3

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