益生菌对阿尔茨海默病的干预作用：随机对照试验的系统评价与Meta分析(英文)

Lü  Meng-ze1; 2; 3; 4; WANG Ru-yu 1; 2; 3; 4; ZHOU Zi-jing 1; 2; 3; 4; HAO Zong-yun 1; 2; 3; 4; CHEN  Si-qi1; 2; 3; 4; LIN Hong-ji 1; 2; 3; 4; GUO Yang-yang 1; 2; 3; 4; ZHAO Zi-hao 1; 2; 3; 4; BA Ya-nan 1; 2; 3; 4; YANG Yi-meng 1; 2; 3; 4; YANG Heng-yao 1; 2; 3; 4; MA Jun 1; 2; 3; 4; 5*

doi:10.16098/j.issn.0529-1356.2026.04.003

PDF(450 KB)

解剖学报 ›› 2026, Vol. 57 ›› Issue (4) : 410-417. DOI: 10.16098/j.issn.0529-1356.2026.04.003

神经生物学

益生菌对阿尔茨海默病的干预作用：随机对照试验的系统评价与Meta分析(英文)

吕孟泽^1,2,3,4王如玉^1,2,3,4周紫荆^1,2,3,4郝宗运^1,2,3,4陈思琪^1,2,3,4林闳基^1,2,3,4郭阳阳^1,2,3,4赵子豪^1,2,3,4巴雅楠^1,2,3,4杨怡萌^1,2,3,4杨烜瑶^1,2,3,4马隽^1,2,3,4,5*

作者信息 +

Effect of probiotics on Alzheimer’s disease: a system review and meta-analysis of randomized controlled trials

LÜ Meng-ze^1,2,3,4, WANG Ru-yu^1,2,3,4, ZHOU Zi-jing^1,2,3,4, HAO Zong-yun^1,2,3,4, CHEN Si-qi^1,2,3,4, LIN Hong-ji^1,2,3,4, GUO Yang-yang^1,2,3,4, ZHAO Zi-hao^1,2,3,4, BA Ya-nan^1,2,3,4, YANG Yi-meng^1,2,3,4, YANG Heng-yao^1,2,3,4, MA Jun^1,2,3,4,5*

Author information +

文章历史 +

摘要

目的探讨益生菌对阿尔茨海默病（AD）的干预作用。方法系统性回顾分析与评价益生菌治疗阿尔茨海默病（AD）的效果，涵盖多个结局指标。研究通过检索9个数据库，文章语言不限，研究时间截至2025年3月7日，而后，使用随机效应模型进行了Meta分析，设置标准化均数差（SMD）、I2统计量和95%置信区间（CI）。结果最终纳入8项随机对照试验（RCT），其中益生菌组261人，安慰剂组256人。Meta分析表明，益生菌可显著改善AD患者认知功能，提升总抗氧化能力，缓解促氧化过程和炎症。结论益生菌补充剂对于改善个体认知缺陷和提高认知能力有重要意义，为临床应用益生菌治疗AD提供了理论依据和可行性建议。

Abstract

Objective To explore possible healing advantages of probiotics in controlling Alzheimer’s diseese(AD). Methods Conducting an extensive evaluation of probiotics’ healing effects, encompassing various facets and perspectives. We conducted an extensive search across 9 databases with no language restrictions, spanning from the inception of research to March 7, 2025, to identify randomized controlled studies examining the impact of probiotic therapy on. A meta-analysis was then performed using random-effects models to determine the standardized mean difference (SMD), I2 statistic, and 95% confidence interval (CI). Results The study eventually incorporated eight randomized controlled trials (RCT), with 261 individuals in probiotic cohort and 256 in the placebo group. Probiotics significantly improved cognitive function, promoted total anti-oxidant capacity and mitigated the pro-oxidant process and inflammation. Conclusion The significance of probiotic supplements lies in their ability to enhance cognitive abilities in individuals with cognitive deficits, offering both theoretical underpinnings and actionable advice for using probiotics clinically in AD treatment.

导出引用

吕孟泽王如玉周紫荆郝宗运陈思琪林闳基郭阳阳赵子豪巴雅楠杨怡萌杨烜瑶马隽. 益生菌对阿尔茨海默病的干预作用：随机对照试验的系统评价与Meta分析(英文)[J]. 解剖学报. 2026, 57(4): 410-417 https://doi.org/10.16098/j.issn.0529-1356.2026.04.003

LÜ Meng-ze , WANG Ru-yu 1, 2, 3, 4, ZHOU Zi-jing HAO Zong-yun CHEN Si-qi LIN Hong-ji GUO Yang-yang ZHAO Zi-hao BA Ya-nan YANG Yi-meng YANG Heng-yao MA Jun. Effect of probiotics on Alzheimer’s disease: a system review and meta-analysis of randomized controlled trials[J]. Acta Anatomica Sinica. 2026, 57(4): 410-417 https://doi.org/10.16098/j.issn.0529-1356.2026.04.003

中图分类号： R3

参考文献

[1] Liang CS, Li DJ, Yang FC, et al. Mortality rates in Alzheimer’s disease and non-Alzheimer’s dementias: a systematic review and meta-analysis [J]. Lancet Healthy Longev, 2021, 2(8): e479-e488.

[2] Liang S, Wang T, Hu X, et al. Administration of lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress [J]. Neuroscience, 2015, 310: 561-577.

[3] Chen C, Ahn EH, Kang SS, et al. Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model [J]. Sci Adv, 2020, 6(31): eaba0466.

[4] Vogt NM, Kerby RL, Dill-mcfarland KA, et al. Gut microbiome alterations in Alzheimer’s disease [J]. Sci Rep, 2017, 7(1): 13537.

[5] Guilherme MDS, Nguyen VTT, Reinhardt C, et al. Impact of gut microbiome manipulation in 5xFAD mice on Alzheimer’s disease-like pathology [J]. Microorganisms, 2021, 9(4): 815.

[6] Kim MS, Kim Y, Choi H, et al. Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model [J]. Gut, 2020, 69(2): 283-294.

[7] Cumpston MS, Mckenzie JE, Welch VA, et al. Strengthening systematic reviews in public health: guidance in the Cochrane Handbook for Systematic Reviews of Interventions, 2nd edition [J]. J Public Health (Oxf), 2022, 44(4): e588-e592.

[8] Agahi A, Hamidi GA, Daneshvar R, et al. Does severity of Alzheimer’s disease contribute to its responsiveness to modifying gut microbiota? a double blind clinical trial [J]. Front Neurol, 2018, 9: 662.

[9] Akhgarjand C, Vahabi Z, Shab-Bidar S, et al. Effects of probiotic supplements on cognition, anxiety, and physical activity in subjects with mild and moderate Alzheimer’s disease: a randomized, double-blind, and placebo-controlled study [J]. Front Aging Neurosci, 2022, 14: 1032494.

[10] Akhgarjand C, Vahabi Z, Shab-Bidar S, et al. The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled study [J]. Inflammopharmacology, 2024, 32(2): 1413-1420.

[11] Akbari E, Asemi Z, Daneshvar Kakhaki R, et al. Effect of probiotic supplementation on cognitive function and metabolic status in Alzheimer’s disease: a randomized, double-blind and controlled trial [J]. Front Aging Neurosci, 2016, 8: 256.

[12] Xiao J, Katsumata N, Bernier F, et al. Probiotic bifidobacterium breve in improving cognitive functions of older adults with suspected mild cognitive impairment: a randomized, double-blind, placebo-controlled trial [J]. J Alzheimers Dis, 2020, 77(1): 139-147.

[13] Tamtaji OR, Heidari-Soureshjani R, Mirhosseini N, et al. Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer’s disease: a randomized, double-blind, controlled trial [J]. Clin Nutr, 2019, 38(6): 2569-2575.

[14] Kobayashi Y, Kuhara T, Oki M, et al. Effects of bifidobacterium breve A1 on the cognitive function of older adults with memory complaints: a randomised, double-blind, placebo-controlled trial [J]. Benef Microbes, 2019, 10(5): 511-520.

[15] Fei Y, Wang R, Lu J, et al. Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment [J]. Geriatr Nurs, 2023, 51: 167-175.

[16] Xiang S, Ji JL, Li S, et al. Efficacy and Safety of probiotics for the treatment of Alzheimer’s disease, mild cognitive impairment, and Parkinson’s disease: a systematic review and meta-analysis [J]. Front Aging Neurosci, 2022, 14: 730036.

[17] Fekete M, Lehoczki A, Major D, et al. Exploring the influence of gut-brain axis modulation on cognitive health: a comprehensive review of prebiotics, probiotics, and symbiotics [J]. Nutrients, 2024, 16(6): 789.

[18] Ma YY, Li X, Yu JT, et al. Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside [J]. Transl Neurodegener, 2024, 13(1): 12.

[19] Dasuri K, Zhang L, Keller JN. Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis [J]. Free Radic Biol Med, 2013, 62: 170-185.

[20] Scuto M, Rampulla F, Reali GM, et al. Hormetic nutrition and redox regulation in gut-brain axis disorders [J]. Antioxidants (Basel), 2024, 13(4): 484.

[21] Mishra V, Yadav D, Solanki KS, et al. A review on the protective effects of probiotics against Alzheimer’s disease [J]. Biology (Basel), 2023, 13(1): 8.

[22] Beltrán-Velasco AI, Reiriz M, Uceda S, et al. Lactiplantibacillus (lactobacillus) plantarum as a complementary treatment to improve symptomatology in neurodegenerative disease: a systematic review of open access literature [J]. Int J Mol Sci, 2024, 25(5): 3010.

基金

Natural Science Foundation of China (82571825); Natural Science Foundation of Hebei Province (Key Project of Joint Funding for Innovative Development of Precision Medicine, H2025206168); Natural Science Foundation of Hebei Province (H2023206266); Industry-University-Research Project of Universities Stationed in Hebei Collaborative with Shijiazhuang (241200073A); Hebei Province International Science and Technology Cooperation Key Project (25292401D); Scientific Research Project of Higher Education Institutions in Hebei Province (CXZX2025007)