邻苯二甲酸二(2-乙基己基)酯促进多囊卵巢综合征发生发展的机制

doi:10.16098/j.issn.0529-1356.2025.05.016

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解剖学报 ›› 2025, Vol. 56 ›› Issue (5) : 625-633. DOI: 10.16098/j.issn.0529-1356.2025.05.016

综述

邻苯二甲酸二(2-乙基己基)酯促进多囊卵巢综合征发生发展的机制

蔡亮¹ 冯安妮¹ 陈玉华¹肖玉波² 莫中成¹ 谢远杰^1*

作者信息 +

Mechanism of di-(2-ethylhexyl) phthalate promoting the development of polycystic ovary syndrome

CAI Liang¹ FENG An-ni¹ CHEN Yu-hua¹ XIAO Yu-bo² MO Zhong-cheng¹ XIE Yuan-jie^1*

Author information +

文章历史 +

摘要

邻苯二甲酸二（2-乙基己基）酯（DEHP）是塑料制品中普遍存在的一种环境污染物，对女性生殖系统有毒性作用。DEHP能作用于女性下丘脑-垂体-卵巢轴，干扰孕激素、睾酮和雌二醇的合成，影响糖脂代谢，加剧胰岛素抵抗和肥胖等代谢紊乱，并诱导卵母细胞或颗粒细胞氧化应激、过度自噬以及焦亡对卵巢造成的损伤；同时能通过表观遗传修饰影响卵泡发育相关基因的表达而抑制卵泡成熟，促进多囊卵巢综合征的发生发展。我们系统总结了DEHP干扰卵巢功能、诱导多囊卵巢综合征的相关机制，以期为防治环境污染物危害女性生殖健康的研究提供参考。

Abstract

Di-(2-ethylhexyl) phthalate (DEHP) is an environmental pollutant commonly found in plastic products and has toxic effects on female reproductive system. DEHP can interfere with the synthesis of progesterone, testosterone and estradiol through female hypothalamic-pituitary-ovarian axis, aggravate insulin resistance and obesity by affecting glucose and lipid metabolism, and cause ovarian damage through inducing oxidative stress, excessive autophagy and pyroptosis of oocyte or granulosa cells. It can also alter epigenetic genes relating to follicular development and prevent follicles from mature. These factors are closely contribute to the pathogenesis of polycystic ovary syndrome. We systematically summarizes the mechanism of DEHP interfering with ovarian function and inducing polycystic ovary syndrome, in order to provide help for the prevention and treatment of female reproductive injury from environmental pollutant.

导出引用

蔡亮冯安妮陈玉华肖玉波莫中成谢远杰. 邻苯二甲酸二(2-乙基己基)酯促进多囊卵巢综合征发生发展的机制[J]. 解剖学报. 2025, 56(5): 625-633 https://doi.org/10.16098/j.issn.0529-1356.2025.05.016

CAI Liang FENG An-ni CHEN Yu-hua XIAO Yu-bo MO Zhong-cheng XIE Yuan-jie. Mechanism of di-(2-ethylhexyl) phthalate promoting the development of polycystic ovary syndrome[J]. Acta Anatomica Sinica. 2025, 56(5): 625-633 https://doi.org/10.16098/j.issn.0529-1356.2025.05.016

中图分类号： R321.1 R711.75

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