目的 基于网络药理学、分子对接技术及细胞实验探究玉竹（POD）提取物对阿尔茨海默病细胞炎症的调节作用。 方法 筛选玉竹作用于阿尔茨海默病的靶点，进行基因本体论(GO)功能及京都基因和基因组百科全书(KEGG)富集分析；再利用分子对接技术预测玉竹中活性成分与核心靶点蛋白的结合模式；然后利用脂多糖(LPS)诱导神经小胶质细胞BV2炎症细胞模型。玉竹提取物处理细胞模型24 h后收集细胞，通过Real-time PCR检测基因的表达。 结果 筛选得到8种玉竹活性成分，172个作用靶点，GO功能分析得到包括蛋白磷酸化、信号转导等生物过程，蛋白结合、ATP结合等分子功能。KEGG富集得到PI3K/Akt、cAMP等信号通路。分子对接结果显示，玉竹活性成分与表皮生长因子受体（EGFR）、原癌基因酪氨酸蛋白激酶Src（SRC）、肿瘤坏死因子（TNF）、STAT3等靶点具有较好的结合活性。通过Real-time PCR实验，LPS诱导的炎症细胞模型中诱导型一氧化氮合酶（iNOS）、环氧合酶-2（PTGS2）、白细胞介素(IL)-6及IL-1β基因表达显著上调。玉竹提取物处理炎症模型24 h后可以显著下调TNF-α表达，STAT3表达上调，SRC及EGFR表达无显著变化。 结论 网络药理学提示，玉竹可能通过作用 EGFR、SRC、TNF、STAT3等靶点发挥抗阿尔茨海默病的作用。实验结果提示，玉竹提取物通过作用于TNF-α发挥抗炎作用，进而可能发挥缓解阿尔茨海默病的作用。 

Objective To investigate the potential mechanism of action of polygonatum odoratum in treating Alzheimer’s disease through the utilization of network pharmacology and molecular docking techniques.    Methods The methods employed include target screening, Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and molecular docking simulations to assess the binding interactions between the active compounds in polygonatum odoratum (POD) and the key target proteins associated with Alzheimer’s disease. Subsequently, lipopolysaccharide（LPS）was used to induce an inflammatory cell model in BV2 microglial cells. After treating the cell model with POD extract for 24 hours, the cells were collected, and the expression of the target genes were detected by Real-time PCR.    Results Eight active ingredients and 172 targets of POD were screened. The biological processes such as protein phosphorylation and signal transduction, protein binding and ATP binding were obtained by GO functional analysis. KEGG enrichment yielded PI3K/Akt, cAMP and other signaling pathways. The molecular docking result  showed that the active ingredient of POD had well binding activity with epidermal growth factor receptor (EGFR), proto-oncogene tyrosine-protein kinase Src (SRC), tumor necrosis factor （TNF）, STAT3. Through Real-time PCR experiments, the gene expressions of inducible nitric oxide synthase (iNOS), prostaglandin G/H synthase 2(PTGS2), interleukin (IL) -6, and IL-1β in the LPS-induced inflammatory cell model were significantly upregulated. After treating the inflammatory model with POD extract for 24 hours, the expression of TNF-α was significantly reduced, the expression of STAT3 was upregulated, there were no significant changes in the expressions of SRC and EGFR.    Conclusion Network pharmacology suggests polygonatum odoratum’s potential anti-Alzheimer’s effects may be mediated through its interaction with targets such as EGFR, TNF, SRC, and STAT3. The experimental results  suggest that polygonatum odoratum exerts an anti-inflammatory effect by acting on TNF-α, which may further alleviate the symptoms of Alzheimer’s disease.