细胞力学微环境中Piezo1下游信号通路的研究进展

韩卓远; 彭慧; 翟效月; 符园园

doi:10.16098/j.issn.0529-1356.2025.01.016

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解剖学报 ›› 2025, Vol. 56 ›› Issue (1) : 120-126. DOI: 10.16098/j.issn.0529-1356.2025.01.016

综述

细胞力学微环境中Piezo1下游信号通路的研究进展

韩卓远¹彭慧²翟效月³符园园^3*

作者信息 +

Research progress of downstream signal pathway of Piezo1 in cell mechanics microenvironment

HAN Zhuo-yuan¹ PENG Hui² ZHAI Xiao-yue³ FU Yuan-yuan^3*

Author information +

文章历史 +

摘要

细胞所处的微环境存在多种力学信号，具有时间和空间变化性，共同调控细胞增殖、分化和迁移等组织学过程。Piezo1是一种机械敏感性阳离子通道，作为力传感器响应细胞微环境的变化，将信号传递给下游通路，参与多种生命活动。本文中我们对Piezo1的工作原理、相关信号通路和活性调节进行了综述，以期归纳Piezo1调控的下游信号通路，为阻抑或延缓相关疾病提供理论依据。

Abstract

There are a variety of mechanical signals in the microenvironment of cells, which have temporal and spatial variability, which jointly regulate the histological processes such as cell proliferation, differentiation and migration. Piezo1 is a mechanically sensitive cationic channel. As a force sensor, it transmits signals to downstream pathways and participates in a variety of life activities in response to changes in the cell microenvironment. In this paper, the common signal pathways of Piezo1 were reviewed in order to identify the downstream signaling pathways regulated by Piezo1, thereby providing theoretical basis for inhibiting or delaying related diseases.

关键词

Piezo1

/ 机械力 / 细胞外基质

Key words

/ Piezo1 / Mechanical force / Extracellular matrix

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导出引用

韩卓远彭慧翟效月符园园. 细胞力学微环境中Piezo1下游信号通路的研究进展[J]. 解剖学报. 2025, 56(1): 120-126 https://doi.org/10.16098/j.issn.0529-1356.2025.01.016

HAN Zhuo-yuan PENG Hui ZHAI Xiao-yue FU Yuan-yuan. Research progress of downstream signal pathway of Piezo1 in cell mechanics microenvironment[J]. Acta Anatomica Sinica. 2025, 56(1): 120-126 https://doi.org/10.16098/j.issn.0529-1356.2025.01.016

中图分类号： R34

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