金属离子在难治性癫痫发病机制中的研究进展

李昊; 张莹; 刘媛媛

doi:10.16098/j.issn.0529-1356.2024.05.017

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解剖学报 ›› 2024, Vol. 55 ›› Issue (5) : 641-646. DOI: 10.16098/j.issn.0529-1356.2024.05.017

综述

金属离子在难治性癫痫发病机制中的研究进展

李昊^1,2 张莹³ 刘媛媛^1,2*

作者信息 +

Current progress of metal ions in the pathogenesis of refractory epilepsy

LI Hao^1,2 ZHANG Ying³ LIU Yuan-yuan^1,2*

Author information +

文章历史 +

摘要

癫痫是一种常见的由大脑异常电活动引起的慢性神经系统疾病，其发病机制尚未完全阐明。近年来有越来越多研究证明，大脑中的铁、锌、铜参与癫痫的发生发展过程，可能通过影响相应的离子通道的功能、膜电位的平衡、动作电位的传导、氧化还原等方面，进而影响神经元的兴奋性和信号传导。本文中我们就此进行综述，旨在增进我们对癫痫发病机制的理解，为寻找基于金属离子防治癫痫策略提供新思路。

Abstract

Epilepsy is a common chronic neurological disorder caused by abnormal electrical activity in the brain, and its pathogenesis has not been fully clarified. In recent years, more and more studies have shown that iron, zinc and copper in the brain are involved in the occurrence and development of epilepsy. These metal ions possibly play a role in epileptogenesis by affecting neuronal excitability and signal transduction through alterating ion channel function, potential balance, action potential propagation, redox and so on. In this review, we mainly analyse the effects of these metal ions on epilepsy, in order to explore the underlying mechanisms of epilepsy and provide promising therapeutic strategies for epilepsy based on metal ions.

关键词

癫痫｜金属离子｜神经系统｜离子通道｜螯合治疗

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导出引用

李昊张莹刘媛媛. 金属离子在难治性癫痫发病机制中的研究进展[J]. 解剖学报. 2024, 55(5): 641-646 https://doi.org/10.16098/j.issn.0529-1356.2024.05.017

LI Hao ZHANG Ying LIU Yuan-yuan. Current progress of metal ions in the pathogenesis of refractory epilepsy [J]. Acta Anatomica Sinica. 2024, 55(5): 641-646 https://doi.org/10.16098/j.issn.0529-1356.2024.05.017

中图分类号： R741

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