环状RNA在阿尔茨海默病中的作用及研究进展

王宏方; 耿丹丹; 张润姣; 刘清; 李一博; 王磊

doi:10.16098/j.issn.0529-1356.2023.04.017

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解剖学报 ›› 2023, Vol. 54 ›› Issue (4) : 490-494. DOI: 10.16098/j.issn.0529-1356.2023.04.017

综述

环状RNA在阿尔茨海默病中的作用及研究进展

王宏方¹ 耿丹丹^1,2 张润姣¹ 刘清¹ 李一博¹ 王磊^1,2*

作者信息 +

Role and research progress of circular RNA in Alzheimer’s disease #br#

#br#

WANG Hongfang¹ GENG Dan-dan^1,2 ZHANG Run-jiao¹ LIU Qing¹ LI Yi-bo¹ WANG Lei^1,2*

Author information +

文章历史 +

摘要

环状RNA（circRNA）是一类内源性表达的非编码RNA，通过反向剪接共价闭合环化而形成。近年来，已鉴定出多种在真核生物中具有高度保守性和细胞类型特异性的circRNA。阿尔茨海默病（AD）是常见的神经退行性疾病，是老年痴呆的主要原因。近年来的研究表明，circRNA参与了AD病理进程的发生发展，如β-淀粉样蛋白（Aβ）代谢、神经元分化和炎症损伤、氧化应激、自噬以及突触可塑性。我们就circRNA在AD病理中的作用及应用价值进行综述，为circRNA在AD诊断和治疗中的应用提供理论基础。

Abstract

The circular RNA (circRNA) is a class of endogenous expressed non-coding RNA that are formed by covalently closed cyclization through reverse splicing. In recent years, a variety of highly conserved and cell-type specific circRNA have been identified in eukaryotes. Alzheimer’s disease (AD) is a common neurodegenerative disease and the most common cause of dementia in the elderly. Recent studies had shown that circRNA was involved in the pathogenesis and development of AD, such as amyloid β-protein (Aβ) metabolic, neuroinflammation, oxidative stress, autophagy and synaptic plasticity. The role and application value of circRNA in AD pathology are reviewed to provide a theoretical basis for the application of circRNA in the treatment and diagnosis of AD.

导出引用

王宏方耿丹丹张润姣刘清李一博王磊. 环状RNA在阿尔茨海默病中的作用及研究进展[J]. 解剖学报. 2023, 54(4): 490-494 https://doi.org/10.16098/j.issn.0529-1356.2023.04.017

WANG Hongfang GENG Dan-dan ZHANG Run-jiao LIU Qing LI Yi-bo WANG Lei. Role and research progress of circular RNA in Alzheimer’s disease #br#

#br#

[J]. Acta Anatomica Sinica. 2023, 54(4): 490-494 https://doi.org/10.16098/j.issn.0529-1356.2023.04.017

中图分类号： R741

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